There are 805 entries in the database including 721 alleles, providing 10183 curated data.
The entries are distributed as follows (click on chart category to see all category entries).
There are 67 hybrid alleles (list). 548 alleles are referenced in GenBank.
Data were curated from 467 references: 387 articles and 80 abstracts or other sources. The number of references per entry for articles and abstracts is distributed as follows.
Reference graph
Frequency of reports
The table shows which entries listed in the database are more or less frequently reported in the literature.
Phenotypes for RH antigens other than D (RH1) have been reported for 445 entries (62.68%)
. The numbering in the table below follows the ISBT numerical nomenclature (column 2 for RH2, column 3 for RH3, etc.)
RH Ag
2
3
4
5
6
7
8
9
10
11
12
17
18
19
20
22
23
26
27
29
30
31
32
33
34
35
36
37
40
42
43
45
48
50
52
53
54
56
58
Positive
10
1
9
3
2
1
1
1
13
2
1
4
8
1
8
1
6
3
1
4
3
1
1
1
6
5
15
6
Negative
206
381
97
36
2
1
9
5
14
2
9
1
12
11
1
43
2
1
34
7
21
7
2
1
4
5
13
2
2
10
23
14
8
19
4
2
Overview of RHD alleles
There are 710RHD alleles in the database. A majority has been reported at least once in an article or abstract. A D phenotype was reported at least once for 616 alleles (85.44%).
All the D phenotypes reported for these alleles (curated from the literature), are:
Testing with monoclonal anti-D has been reported for 239 alleles (33.66%).
A D antigen density (Ag/RBC) has been reported for 150 alleles (21.13%).
The association with CcEe phenotypes has been reported at least once for 499 alleles (70.28%).
The main haplotypes associated for each allele (curated from the literature), are:
Regarding anti-D formation in carriers:
111 alleles (15.63%) have some data reported regarding anti-D formation in carriers,
77 alleles (10.85%) have been reported at least once with allo-anti-D, including reports in conference abstracts.
No anti-D has ever been reported for 501 alleles (70.56%).
Variant count per position in RHD exons
Nucleotide
Blue columns: mutations except those related to RHCE, green columns: mutations found in RHCE.
Protein
Blue columns: mutations except those related to RHCE, green columns: mutations found in RHCE.