RHD*31T,602G,667G,819A
(ISBT table: not listed)
This entry is an RHD allele.
RHCE*DAR3.1(31 T), RHD(R11C,T201R,F223V), RHD(R11C,T201R,F223V,A273A), RHD*31C>T,602C>G,667T>G,819G>A, RHD*31T,602G,667G,819A, RHD*c.31T,c.602G,c.667G,c.819A,
Molecular data
Nucleotides:
31C>T; 602C>G; 667T>G; 819G>A;
Amino acids: R11C; T201R; F223V; A273A;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
- "While this is the more likely allele, other interpretations are also consistent with the data." Allele is listed at the RHCE locus.
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D positive (last update: March 7, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2, -3, -8, -19, -31, -58,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce (last update: Aug. 15, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: July 28, 2020)Detailed information
-
GA Denomme et al. Vox Sanguinis (2019)
- Ab specificity: CELO (RH58)
- Number (auto- or allo-):
- Number listed as allo-: 1
- Number listed as auto-:
- Number of carriers of the allele assessed:
- DAT: negative
- Autologuous control:
- Elution:
- Autoadsorption:
- Titer:
- Was anti-LW excluded?:
- Other antibodies detected:
- Cross matches (with Ab and RBCs from different partial types): The serum was reactive with 3 hrB– , 1 hrS– , 1 Rh:-51[Mar ], and 1 Dc(e), but non-reactive with 3 Rhnull cells, 5 out of 7 D– – cells, and 1 Dc-/Dc- sample. It was non-reactive with Rhnull and Rh: 58 (CELO ) RBCs.
- Transfusion history:
- Pregnancy history:
- Anti-D Ig history:
- Context:
- Hemolytic consequences:
- Comment:
Antibody specificity: CELO (RH58)
Detailed information
-
GA Denomme et al. Vox Sanguinis (2019)
- Ab specificity: CELO (RH58)
- Number (auto- or allo-):
- Number listed as allo-: 1
- Number listed as auto-:
- Number of carriers of the allele assessed:
- DAT: negative
- Autologuous control:
- Elution:
- Autoadsorption:
- Titer:
- Was anti-LW excluded?:
- Other antibodies detected:
- Cross matches (with Ab and RBCs from different partial types): The serum was reactive with 3 hrB– , 1 hrS– , 1 Rh:-51[Mar ], and 1 Dc(e), but non-reactive with 3 Rhnull cells, 5 out of 7 D– – cells, and 1 Dc-/Dc- sample. It was non-reactive with Rhnull and Rh: 58 (CELO ) RBCs.
- Transfusion history:
- Pregnancy history:
- Anti-D Ig history:
- Context:
- Hemolytic consequences:
- Comment:
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: exceptional description(s) (last update: March 7, 2020)Structure mapping
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References
- GA Denomme et al. A novel weak D 4.0-related allele and RHCE*ceCF defines a new rh haplotype in an autologous donor with an antibody to a high frequency antigen Vox Sanguinis, 2019. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 8, 2021