RHD*09.05 - RHD*DAR5
(ISBT table: RHD partial D v5.0)
This entry is an RHD allele.
RHD(T201R,F223V,A273A,P291R), RHD(T201R,F223V,P291R), RHD*602C>G,667T>G,819G>A,872C>G, RHD*602G,667G,819A,872G, RHD*602G,667G,819A,872G (weak D type 4.3, DAR5), weak D type 4.3,
Molecular data
Phenotype
Main D phenotype: variable/discrepant (last update: June 11, 2020)Reports by D phenotype
- Undetailed ambiguous D phenotype
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDweakDtype4.3.htm
- Weak D phenotype
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDweakDtype4.3.htm
- DEL
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDweakDtype4.3.htm
- D negative
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDweakDtype4.3.htm
Other RH phenotypes: RH:-2, -3,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce (last update: Aug. 15, 2020)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 34 | 1 | 1 | 0 |
Ce | 0 | 0 | 0 | |
cE | 0 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: many descriptions, Austrian (last update: June 11, 2020)Detailed reports
-
1/2427 among first-time donors without D expression but with amplification of RHD exons 4, 7, and 10 whithin 44,743 donors tested in the Austrian population, Upper Austria
(samples probably included in
22288371 ) -
31/23330 donor samples with D negative phenotype tested for RHD exons 4, 7 and 10 (94 were PCR positive, 74 weak D or DEL in subsequent serologic analysis) in the Austrian population, Upper Austria
(samples probably included in
22288371 ) - 1/25 donors with "weak D or questionnable D status" explored by NGS to compare with Sanger sequencing in the Austrian population, Upper Austria
- 5/101 among 2450 donors with D negative phenotype tested for RHD specific polymorphisms (101 were positive for the polymorphisms) African descent in Brazilian (Southeast and Northeast Brazil)
-
34/29050 (only 2 new probands) donors with D negative phenotype Caucasian, in the Austrian population, Upper Austria
(probably includes samples from
19170995 and17655577 ) - 2 tp 10 /136000 among about 136.000 donors with D negative phenotype, systematically tested for the presence of the RHD gene; the RHD gene was detected in 300 donors in the German population (some samples may overlap with other studies)
-
1/46,756 first time donors with D negative phenotype, tested for RHD exon 7 and adsorption-elution with a polyclonal anti-D in the German population (Northern)
(overlaps with
999999913 ; some samples may overlap with full publications) (overlaps with999999988 ; some samples may overlap with full publications)
Allele or phenotype frequency
Structure mapping
Movement | Mouse Input | Touch Input | ||
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Rotation | Primary Mouse Button | Single touch | ||
Translation | Middle Mouse Button or Ctrl+Primary | Triple touch | ||
Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
Slab | Ctrl+Second | Not Available |
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Polin H et al. Effective molecular RHD typing strategy for blood donations. Transfusion, 2007. [Citation] [RHeference]
- Flegel WA et al. D variants at the RhD vestibule in the weak D type 4 and Eurasian D clusters. Transfusion, 2009. [Citation] [RHeference]
- Polin H et al. Identification of RHD alleles with the potential of anti-D immunization among seemingly D- blood donors in Upper Austria. Transfusion, 2009. [Citation] [RHeference]
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
- Stabentheiner S et al. Overcoming methodical limits of standard RHD genotyping by next-generation sequencing. Vox Sang, 2011. [Citation] [RHeference]
- Mota M et al. RHD allelic identification among D-Brazilian blood donors as a routine test using pools of DNA. J Clin Lab Anal, 2012. [Citation] [RHeference]
- Wagner FF et al. RHD PCR of blood donors in Northern Germany: use of adsorption/elution to determine D antigen status Vox Sanguinis, 2012. — Abstract — [RHeference]
- F F Wagner et al. Single Adsorption / Elution with Anti-D May Be Insufficient to Determine the D Antigen Status of Very Weak DEL Alleles Transfusion, 2012. — Abstract — [RHeference]
- Polin H et al. On the trail of anti-CDE to unexpected highlights of the RHD*weak 4.3 allele in the Upper Austrian population. Vox Sang, 2012. [Citation] [RHeference]
- Wagner F. et al. Results of more than ten years testing of RhD negative first time donors by RHD PCR Transfus Med Hemother, 2019. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: June 11, 2020