RHD*763A<br /><small>(ISBT table: not listed)</small>

Molecular Data Phenotype Haplotype Alloimmunization Reports 2D diagram Structure Links References

RHD*763A
(ISBT table: not listed)

This entry is an RHD allele.

RHD(G255R), RHD(G255R) [763A], RHD*763A, RHD*763G>A,

Download VCF file

Molecular data

Nucleotides: 763G>A;

Amino acids: G255R;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

Extracellular position of one or more amino acid substitutions:

none of the mutations are predicted to affect an extracellular amino acid

Splicing:

Unconventional prediction methods:

Phenotype

Main D phenotype: variable/discrepant (last update: June 16, 2020)

Reports by D phenotype

Other RH phenotypes: RH:-2,

RH:-2 inferred from the reported RHCE phenotypes of the carriers

Serology with monoclonal anti-D

(see also "Doescher A & et al. published on RhesusBase NOTE_4" on the RhesusBase http://www.rhesusbase.info/RHDRHD(G255R).htm)

Antigen Density (Ag/RBC)

More phenotype data

Rhesus Similarity Index

Haplotype

Main CcEe phenotype association: ce (last update: Aug. 15, 2020)

Number of samples reported by haplotype
	ce	Ce	cE
ce	0	1	1
Ce		0	0
cE			0
CE

Reports by CcEe phenotype

with ccEe

with Ccee

Main allele association:

Reports by allele association

Alloimmunization

Antibodies in carriers

Antibody specificity: D (RH1)

Summary: no published cases (last update: Nov. 17, 2019)

Detailed information

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Reports

Summary: rare descriptions, in mainly Caucasian populations (last update: June 16, 2020)

Detailed reports

1/430 samples with ambigous D phenotype Caucasian, in the French population (Table S1)
1/231 231 donors with weak D phenotype in the Argentinean population (Northwestern Argentina)
1 sample in the German population (North West Germany) (see also "Doescher A & et al. published on RhesusBase NOTE_4" on the RhesusBase http://www.rhesusbase.info/RHDRHD(G255R).htm)

Allele or phenotype frequency

2D diagram

Structure mapping

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Zoom	Scroll Wheel or Second Mouse Button or Shift+Primary	Pinch (double touch)
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Links

The Human RhesusBase
Genbank: JQ405074
Erythrogene

References

Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
Fichou Y et al. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles. Transfusion, 2013. [Citation] [RHeference]
Trucco Boggione C et al. Characterization of RHD locus polymorphism in D negative and D variant donors from Northwestern Argentina. Transfusion, 2019. [Citation] [RHeference]
Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]

Last update: June 16, 2020

RHD*763A(ISBT table: not listed)