RHD*03.07 - RHD*DIII.07
(ISBT table: RHD partial D v5.0)
This entry is an hybrid RHD allele.
DIII type 7, RHD(1)-RHce(2)-DIIIa(3-10), RHD(I60L,S68N,S103P,A137V,N152T,T201R,F223V), RHD(V50V,I60L,S67S,S68N,S103P,A137V,N152T,T201R,F223V,A273A), RHD*150C,178C,201A,203A,307C,410T,455C,602G,667G,819A, RHD*150T>C,178A>C,201G>A,203G>A,307T>C,410C>T,455A>C,602C>G,667T>G,819G>A, RHD*D-ce(2)-DIIIa, RHD*D-ce(2)-DIIIa (DIII type 7), RHD-RHCE(2)-RHD(A137V,N152T,T201R,F223V),
Molecular data
Nucleotides:
150T>C; 178A>C; 201G>A; 203G>A; 307T>C; 410C>T; 455A>C; 602C>G; 667T>G; 819G>A;
Amino acids: V50V; I60L; S67S; S68N; S103P; A137V; N152T; T201R; F223V; A273A;
Hybrid allele encompassing at least one RHCE exon:
RHD-RHCE(2)-RHD(DIIIa)
Comments on the molecular basis:
- likely the historical phenotypic DIIIb
- see also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDDIIItype7.htm
- "likely the historically defined DIIIb"
- RHD exon 2 not amplified, hybrid allele assumed
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: Nov. 11, 2019)Reports by D phenotype
Other RH phenotypes: RH:-2, -3, 4, -12, 54, 54,
Serology with monoclonal anti-D
- 24 monoclonal anti-D tested; 1 sample; "consistent with results from 16584437" (paragraph Hemagglutination)
- 1 sample; Cross-testing with allo-anti-D: Five anti-D made by DIIIa individuals were nonreactive. Three anti-D made by DIVa individuals, one anti-D made by a DVa individual, and six of seven anti-D made by DVI individuals were reactive.
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce (last update: June 11, 2020)| ce | Ce | cE | CE | |
|---|---|---|---|---|
| ce | 1 | 0 | 0 | 0 |
| Ce | 0 | 0 | 0 | |
| cE | 0 | 0 | ||
| CE | 0 |
Reports by CcEe phenotype
Main allele association: RHCE*01.20.03 (RHCE*ce48C,733G,1006T)Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: exceptional description(s), in South Africans (last update: June 11, 2020)Structure mapping
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| Slab | Ctrl+Second | Not Available |
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Grootkerk-Tax MG et al. RHD(T201R, F223V) cluster analysis in five different ethnic groups and serologic characterization of a new Ethiopian variant DARE, the DIII type 6, and the RHD(F223V). Transfusion, 2006. [Citation] [RHeference]
- Schmid P et al. Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD. Transfusion, 2010. [Citation] [RHeference]
- Westhoff CM et al. DIIIa and DIII Type 5 are encoded by the same allele and are associated with altered RHCE*ce alleles: clinical implications. Transfusion, 2010. [Citation] [RHeference]
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
- Lomas-Francis C et al. DIII Type 7 is likely the original serologically defined DIIIb. Transfusion, 2012. [Citation] [RHeference]
- Reid ME et al. The low-prevalence Rh antigen STEM (RH49) is encoded by two different RHCE*ce818T alleles that are often in cis to RHD*DOL. Transfusion, 2013. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: June 11, 2020