RHD*01N.25
(ISBT table: RHD negative v4.0)
This entry is an RHD allele.
RHD(IVS2-1G>A), RHD*336-1A, RHD*336-1A (IVS2-1A, RHD*01N.25), RHD*336-1G>A,
Molecular data
Nucleotides:
intronic 336G>A;
Amino acids: 0;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
- Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D negative (DEL excluded) (last update: July 28, 2020)Reports by D phenotype
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce? (last update: Aug. 15, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: D negative, at risk for anti-D (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: not expected, see phenotype data
Reports
Summary: exceptional description(s), in the Chinese and Australian populations (last update: April 29, 2020)Detailed reports
- 1/264 samples (or 1/528 alleles) donors with D negative phenotype Korean
- 1/733 donors with D negative phenotype Chinese (Shanghai)
- 1/2027 2027 D posiitive donors, C and/or E positive, screened for RHD exons 4, 5 and 10 and for DEL phenotype in the Australian population
Allele or phenotype frequency
Structure mapping
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Translation | Middle Mouse Button or Ctrl+Primary | Triple touch | ||
Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
Slab | Ctrl+Second | Not Available |
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Kim JY et al. Molecular characterization of D- Korean persons: development of a diagnostic strategy. Transfusion, 2005. [Citation] [RHeference]
- Ye L et al. Molecular bases of unexpressed RHD alleles in Chinese D- persons. Transfusion, 2009. [Citation] [RHeference]
- Ye SH et al. A comprehensive investigation of RHD polymorphisms in the Chinese Han population in Xi'an. Blood Transfus, 2014. [Citation] [RHeference]
- Scott SA et al. The RHD(1227G>A) DEL-associated allele is the most prevalent DEL allele in Australian D- blood donors with C+ and/or E+ phenotypes. Transfusion, 2014. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: June 23, 2020