RHD*1170C
(ISBT table: not listed)
This entry is an RHD allele.
RHD(L390L), RHD*1170C, RHD*1170T>C,
Molecular data
Nucleotides:
1170T>C;
Amino acids: L390L;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
- Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: variable/discrepant (last update: Nov. 17, 2019)Reports by D phenotype
- Undetailed ambiguous D phenotype
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDRHD(L390L).htm
- Discrepant D phenotype (negative or positive depending on anti-D reagents and techniques)
- See also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDRHD(L390L).htm
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce? (last update: Aug. 15, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: exceptional description(s), in French population (last update: Dec. 22, 2019)Structure mapping
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| Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
| Slab | Ctrl+Second | Not Available |
References
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
- Silvy M et al. Weak D and DEL alleles detected by routine SNaPshot genotyping: identification of four novel RHD alleles. Transfusion, 2011. [Citation] [RHeference]
- Chun S et al. The synonymous nucleotide substitution RHD 1056C>G alters mRNA splicing associated with serologically weak D phenotype. J Clin Lab Anal, 2018. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: Aug. 4, 2019