Nucleotides: 147A>G;

Amino acids: Q49Q;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

Extracellular position of one or more amino acid substitutions:

• Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.

Splicing:

• NetGene2 analysis shows only a reduction of the confidence value of Intron 1 donor splice site from 0.86 to 0.81
• effect on splicing predicted in silico

Unconventional prediction methods:

Reports by D phenotype

Other RH phenotypes: RH:

Serology with monoclonal anti-D

Antigen Density (Ag/RBC)

More phenotype data

Reports by CcEe phenotype

Reports by allele association

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Detailed reports

• 1/806 consecutive samples with ambiguous D phenotype in French population (Western France)

Allele or phenotype frequency