RHD*01W.100 - RHD*weak D type 100
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(G263R), RHD*787A, RHD*787A (weak D type 100), RHD*787G>A, weak D type 100,
Molecular data
Phenotype
Main D phenotype: weak D (last update: June 12, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2, -3, -4,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce is the most frequent association (last update: Aug. 15, 2020)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 0 | 9 | 1 | 0 |
Ce | 1 | 0 | 1 | |
cE | 0 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: several descriptions, in individuals of Eastern Asian descent, or compatible with such descent (last update: June 11, 2020)Detailed reports
-
5/45 among 763408 donors, after ruling out partial D phenotypes by using 5 monoclonal anti-D, 75 were considered weak D phenotype and 45 were genotyped Japanese
(5 samples in common with
27183894 ) -
11/226 226 donors considered weak D phenotype, after ruling out partial D phenotypes by using 5 monoclonal anti-D Japanese
(5 samples in common with
26340140 ) - 1/129 (hemizygous) donors with weak D phenotype Thai
- 2 samples unrelated donors Italian
- 1 sample? in the Chinese population (FJ041199)
Allele or phenotype frequency
Structure mapping
Movement | Mouse Input | Touch Input | ||
---|---|---|---|---|
Rotation | Primary Mouse Button | Single touch | ||
Translation | Middle Mouse Button or Ctrl+Primary | Triple touch | ||
Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
Slab | Ctrl+Second | Not Available |
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
- Isa K et al. Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles. Vox Sang, 2016. [Citation] [RHeference]
- Ogasawara K et al. Weak D alleles in Japanese: a c.960G>A silent mutation in exon 7 of the RHD gene that affects D expression. Vox Sang, 2016. [Citation] [RHeference]
- A Matteocci et al. Identification of weak D type 100 in two unrelated italian donors Vox Sanguinis, 2017. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Thongbut J et al. Comprehensive Molecular Analysis of Serologically D-Negative and Weak/Partial D Phenotype in Thai Blood Donors. Transfus Med Hemother, 2020. [Citation] [RHeference]
Last update: Dec. 10, 2020