Nucleotides: 525C>T;

Amino acids: F175F;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

• see also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDRHD(F175L).htm
• nucleotide and amino acid substitutions from the description are incompatible, respectively: c.525C>T and p.F175L, we considered the latter to be the typo
• RHD c.525C>T is reported in the 1000 Genomes project with a prevalence of: Africa: 0.15%. America: 0.14%. East Asia: 0.20%.

Extracellular position of one or more amino acid substitutions:

• none of the mutations are predicted to affect an extracellular amino acid

Splicing:

Unconventional prediction methods:

Reports by D phenotype

Other RH phenotypes: RH:

Serology with monoclonal anti-D

Antigen Density (Ag/RBC)

More phenotype data

Reports by CcEe phenotype

Reports by allele association

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Detailed reports

• 1/163 selected variants included for the development of a genotyping assay mainly in the Dutch population (samples may have been included in other studies)

Allele or phenotype frequency