RHD*165T
(ISBT table: not listed)
This entry is an RHD allele.
DBO-1, RHD(T55T), RHD*165C>T, RHD*165T, RHD*165T (DBO1), weak D(165C>T),
Molecular data
Nucleotides:
165C>T;
Amino acids: T55T;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
- Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.
- transmembrane
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: Nov. 13, 2019)Reports by D phenotype
- Undetailed ambiguous D phenotype
- Heterozygous with RHef00442
- Weak D phenotype
- Heterozygous with RHef00442
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce? (last update: Jan. 8, 2021)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: exceptional description(s), Tibetan and Chinese (last update: June 11, 2020)Detailed reports
- 1/25 donors with "weak D or questionnable D status" explored by NGS to compare with Sanger sequencing in the Austrian population, Upper Austria
- 1 sample? in the Chinese population (DQ309583)
- 1/50 (heterozygous with RHef00442) Tibetan
- 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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References
- National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
- Wei Qing et al. Random survey for RH allele polymorphism among 50 native Tibetans. Open Access Repositorium of the University of Ulm (Germany), 2006. — Thesis — [RHeference]
- Stabentheiner S et al. Overcoming methodical limits of standard RHD genotyping by next-generation sequencing. Vox Sang, 2011. [Citation] [RHeference]
- Reid ME et al. Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease. Blood Cells Mol Dis, 2014. [Citation] [RHeference]
- Chun S et al. The synonymous nucleotide substitution RHD 1056C>G alters mRNA splicing associated with serologically weak D phenotype. J Clin Lab Anal, 2018. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 8, 2021