RHD*497G<br /><small>(ISBT table: not listed)</small>

Molecular Data Phenotype Haplotype Alloimmunization Reports 2D diagram Structure Links References

RHD*497G
(ISBT table: not listed)

This entry is an RHD allele.

DFW-2, RHD(H166R), RHD*497A>G, RHD*497G, RHD*497G (DFW2),

Download VCF file

Molecular data

Nucleotides: 497A>G;

Amino acids: H166R;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

sequencing of RHD exons 1 to 10

Extracellular position of one or more amino acid substitutions:

none of the mutations are predicted to affect an extracellular amino acid

Splicing:

Unconventional prediction methods:

Phenotype

Main D phenotype: variable/discrepant (last update: Aug. 9, 2020)

Reports by D phenotype

Other RH phenotypes: RH:-3, -4,

RH:-3 inferred from the reported RHCE phenotypes of the carriers
RH:-4 inferred from the reported RHCE phenotypes of the carriers

Serology with monoclonal anti-D

unidentifiable pattern, with ALBAclone advanced partial RhD typing kit and Diagast D-screen kit (see abstract for reactivities with specific Ab)

Antigen Density (Ag/RBC)

More phenotype data

Rhesus Similarity Index

Haplotype

Main CcEe phenotype association: Ce (last update: Aug. 9, 2020)

Number of samples reported by haplotype
	ce	Ce	cE
ce	0	0	0
Ce		2	0
cE			0
CE

Reports by CcEe phenotype

with Ce

Main allele association:

Reports by allele association

Alloimmunization

Antibodies in carriers

Antibody specificity: D (RH1)

Summary: no published cases (last update: Aug. 9, 2020)

Detailed information

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Reports

Summary: exceptional description(s), possibly in Chinese and/or Portuguese individuals (last update: Aug. 9, 2020)

Detailed reports

1 sample? reported by a Chinese lab from Guangzhou, Guangdong Province (MK733912)
2 related samples reported by a Portuguese lab

Allele or phenotype frequency

2D diagram

Structure mapping

Movement	Mouse Input	Touch Input
Rotation	Primary Mouse Button	Single touch
Translation	Middle Mouse Button or Ctrl+Primary	Triple touch
Zoom	Scroll Wheel or Second Mouse Button or Shift+Primary	Pinch (double touch)
Slab	Ctrl+Second	Not Available

Links

The Human RhesusBase
Genbank: MK733912
Erythrogene

References

National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
M Rodrigues et al. A novel RHD variant 'DFW-2' Vox Sanguinis, 2009. — Abstract — [RHeference]
Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]

Last update: Aug. 9, 2020

RHD*497G(ISBT table: not listed)