RHD*04.06 - RHD*DIVb
(ISBT table: RHD partial D v5.0)
This entry is an hybrid RHD allele.
DIVb, DIVb (Da.) (obsolete), DIVb type 2, RHD(D350H,G353W,A354N,E398V), RHD(D350H,T351T,G353W,A354N,L390L,E398V), RHD*1048C,1053T,1057T,1059G,1060A,1061A,1170C,1193T, RHD*D-CE(7:1048-9:1193)-D, RHD*D-CE(7:1048-9:1193)-D (DIVb), RHD-RHCE(7-9)-RHD, RHD-RHCE(7:1048-9)-RHD, RHD-RHCE(7:1048-9:1193)-RHD,
Molecular data
Nucleotides:
1048G>C; 1053C>T; 1057GGA>TGG deletion-insertion; 1060GC>AA deletion-insertion; 1170T>C; 1193A>T;
Amino acids: D350H; T351T; G353W; A354N; L390L; E398V;
Hybrid allele encompassing at least one RHCE exon:
RHD-RHCE(7-9)-RHD , RHD-RHCE(7:1048-9)-RHD , RHD-RHCE(7:1048-9:1193)-RHD,
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: variable/discrepant (last update: Nov. 11, 2019)Reports by D phenotype
Other RH phenotypes: RH:-3, -23, -30, 37, -50,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce (last update: Nov. 11, 2019)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 0 | 7 | 0 | 0 |
Ce | 0 | 0 | 0 | |
cE | 0 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: probably allo-anti-D (last update: May 16, 2020)Detailed information
-
Westhoff CM et al. Transfusion (2007)
(Table 3)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 1
- Number listed as allo-:
- Number listed as auto-:
- Number of carriers of the allele assessed: ND
- DAT: ND
- Autologuous control: ND
- Elution: ND
- Autoadsorption: ND
- Titer: ND
- Was anti-LW excluded?: ND
- Other antibodies detected: ND
- Cross matches (with Ab and RBCs from different partial types): ND
- Transfusion history: ND
- Pregnancy history:
- Anti-D Ig history: ND
- Context: ND
- Hemolytic consequences: none
- Comment:
-
Daniels G et al. Br J Haematol (2013)
(review; Table I)
- Ab specificity: D (RH1)
- Number (auto- or allo-):
- Number listed as allo-: no new case detailed (listed as allo-anti-D)
- Number listed as auto-: NA
- Number of carriers of the allele assessed: NA
- DAT: NA
- Autologuous control: NA
- Elution: NA
- Autoadsorption: NA
- Titer: NA
- Was anti-LW excluded?: NA
- Other antibodies detected: NA
- Cross matches (with Ab and RBCs from different partial types): NA
- Transfusion history: NA
- Pregnancy history:
- Anti-D Ig history: NA
- Context: NA
- Hemolytic consequences: NA
- Comment: list of D variants associated with alloanti-D formation
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: few descriptions (last update: April 28, 2020)Structure mapping
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Slab | Ctrl+Second | Not Available |
References
- Rouillac C et al. Transcript analysis of D category phenotypes predicts hybrid Rh D-CE-D proteins associated with alteration of D epitopes. Blood, 1995. [Citation] [RHeference]
- Avent ND et al. Molecular basis of the D variant phenotypes DNU and DII allows localization of critical amino acids required for expression of Rh D epitopes epD3, 4 and 9 to the sixth external domain of the Rh D protein. Br J Haematol, 1997. [Citation] [RHeference]
- Liu W et al. Site-directed mutagenesis of the human D antigen: definition of D epitopes on the sixth external domain of the D protein expressed on K562 cells. Transfusion, 1999. [Citation] [RHeference]
- Avent ND et al. The rhesus blood group system: insights from recent advances in molecular biology. Transfus Med Rev, 1999. [Citation] [RHeference]
- Cowley NM et al. RHD gene mutations and the weak D phenotype: an Australian blood donor study. Vox Sang, 2000. [Citation] [RHeference]
- Westhoff CM et al. Rh complexities: serology and DNA genotyping. Transfusion, 2007. [Citation] [RHeference]
- Schmid P et al. Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD. Transfusion, 2010. [Citation] [RHeference]
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
- Daniels G et al. Variants of RhD--current testing and clinical consequences. Br J Haematol, 2013. [Citation] [RHeference]
- von Zabern I et al. D category IV: a group of clinically relevant and phylogenetically diverse partial D. Transfusion, 2013. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: June 11, 2020