RHD*36 - RHD*DLO
(ISBT table: RHD partial D v5.0)
This entry is an RHD allele.
DLO, RHD(S284L), RHD*851C>T, RHD*851T, RHD*851T (DLO, RHD*36),
Molecular data
Nucleotides:
851C>T;
Amino acids: S284L;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
- AJ585040; "The coding sequence of exons 1 to 5 and 7 to 10 is identical to the standard RHD sequences (accession numbers AJ299020 to AJ299029)."
Extracellular position of one or more amino acid substitutions:
- amino acid substitution at the junction between helix 9 and extracellular loop 5
- none of the mutations are predicted to affect an extracellular amino acid
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: Dec. 28, 2020)Reports by D phenotype
Other RH phenotypes: RH:-3, -4,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Haplotype
Main CcEe phenotype association: Ce (last update: Jan. 8, 2021)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Dec. 28, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: few descriptions, in various populations (last update: Dec. 28, 2020)Detailed reports
- 1/168 among 168 samples referred for weak D phenotype and/or allo anti-D in D positive individuals, 137 were characterized in the study (70 by serology, 67 by molecular analysis, 31 could not be typed because serologic typing was inconclusive and molecular typing could not be performed) in the French population (Caucasian)
- 1/205 weak D phenotype African descent in the French population
- 1/351 out of 351 prenatal patients with discrepant D phenotyping results (population tested 608486 patients) Canada
- 1/246 samples with weak D phenotype reported by a German lab
- 1 sample? in the Chinese population (EF513772)
- 2/353 samples referred for discrepant or weak D typing in the USA population
- 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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References
- National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
- A. Doscher et al. Six new RHD alleles with previously unknown polymorphisms Transfus Med Hemother , 2003. — Abstract — [RHeference]
- Ansart-Pirenne H et al. RhD variants in Caucasians: consequences for checking clinically relevant alleles. Transfusion, 2004. [Citation] [RHeference]
- Noizat-Pirenne F et al. Relevance of RH variants in transfusion of sickle cell patients. Transfus Clin Biol, 2011. [Citation] [RHeference]
- Clarke G et al. Resolving variable maternal D typing using serology and genotyping in selected prenatal patients. Transfusion, 2016. [Citation] [RHeference]
- S Vege et al. RHD Genotyping of Discrepant or Weak D Samples: Over a Year’s Experience. Transfusion, 2017. — Abstract — [RHeference]
- Ji YL et al. RHD genotype and zygosity analysis in the Chinese Southern Han D+, D- and D variant donors using the multiplex ligation-dependent probe amplification assay. Vox Sang, 2017. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
- Vege S et al. Impact of RHD genotyping on transfusion practice in Denmark and the United States and identification of novel RHD alleles. Transfusion, 2021. [Citation] [RHeference]
Last update: Jan. 8, 2021