RHD*01W.32 - RHD*weak D type 32<br /><small>(ISBT table: Weak D and Del v5.0)</small><br />

Molecular Data Phenotype Haplotype Alloimmunization Reports 2D diagram Structure Links References

RHD01W.32 - RHDweak D type 32
(ISBT table: Weak D and Del v5.0)

This entry is an RHD allele.

RHD(I374N), RHD*1121A, RHD*1121A (weak D type 32), RHD*1121T>A, weak D type 32,

Download VCF file

Molecular data

Nucleotides: 1121T>A;

Amino acids: I374N;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

Extracellular position of one or more amino acid substitutions:

none of the mutations are predicted to affect an extracellular amino acid

Splicing:

Unconventional prediction methods:

Phenotype

Main D phenotype: variable/discrepant (last update: Nov. 17, 2019)

Reports by D phenotype

Weak D phenotype
- ISBT classification
Very weak D phenotype
DEL
- adsorption-elution was performed
- adsorption-elution was performed; DCCee sample with probable suppressive effect of C in trans
D negative
- initially typed as D negative
- initially typed as D negative

Other RH phenotypes: RH:-3, -4,

RH:-3 inferred from the reported RHCE phenotypes of the carriers
RH:-4 inferred from the reported RHCE phenotypes of the carriers

Serology with monoclonal anti-D

0 monoclonal IgG anti-D non-reactive with variant, out of 22 monoclonal IgG tested (Table 2)

Antigen Density (Ag/RBC)

49 Ag/RBC, median for 1 sample with 11 IgG anti-D

More phenotype data

Rhesus Similarity Index

Haplotype

Main CcEe phenotype association: Ce (last update: Aug. 15, 2020)

Number of samples reported by haplotype
	ce	Ce	cE
ce	0	1	0
Ce		1	0
cE			0
CE

Reports by CcEe phenotype

with Ccee

with Ce

Main allele association:

Reports by allele association

Alloimmunization

Antibodies in carriers

Antibody specificity: D (RH1)

Summary: no published cases (last update: Nov. 17, 2019)

Detailed information

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Reports

Summary: rare descriptions, Austrian (last update: Dec. 22, 2019)

Detailed reports

2 samples blood donor and "unrelated individual" in the Austrian population
2/23330 donor samples with D negative phenotype tested for RHD exons 4, 7 and 10 (94 were PCR positive, 74 weak D or DEL in subsequent serologic analysis) in the Austrian population, Upper Austria

Allele or phenotype frequency

1/11665 (CI: 1/3704 - 1/66667) estimated allele frequency in individuals with D negative phenotype in the Austrian population, Upper Austria

2D diagram

Structure mapping

Movement	Mouse Input	Touch Input
Rotation	Primary Mouse Button	Single touch
Translation	Middle Mouse Button or Ctrl+Primary	Triple touch
Zoom	Scroll Wheel or Second Mouse Button or Shift+Primary	Pinch (double touch)
Slab	Ctrl+Second	Not Available

Links

The Human RhesusBase
Genbank: AJ580935 AJ580936 AJ580937 AJ580938 AJ580939 AJ580940 AJ580941 AJ580942 AJ580943 AJ580944
Erythrogene

References

International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
Körmöczi GF et al. Novel weak D types 31 and 32: adsorption-elution-supported D antigen analysis and comparison to prevalent weak D types. Transfusion, 2005. [Citation] [RHeference]
Polin H et al. Identification of RHD alleles with the potential of anti-D immunization among seemingly D- blood donors in Upper Austria. Transfusion, 2009. [Citation] [RHeference]
Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]

Last update: Sept. 22, 2019

RHD*01W.32 - RHD*weak D type 32(ISBT table: Weak D and Del v5.0)