partly characterized RHD*06 (DVI) (partly characterized or subtypes not separated)
(ISBT table: not listed)
This entry is partly characterized.
DVI - partly characterized or subtypes not separated,
Molecular data
Nucleotides:
Amino acids:
Hybrid allele encompassing at least one RHCE exon:
NA
Comments on the molecular basis:
- partly characterized
- partly characterized
- subtypes not separated
- subtypes not separated
- typing method not clear
- Table 1; molecular characterization assumed
- PCR pattern, exons 3, 4, 5, 6, 7 and 9
- PCR pattern
- phenotypic description would correspond to RHef00102, but the authors state briefly that the sample is RHD-RHCE(3-5)-RHD, which would be more in accordance with the molecular structure of RHef00106
- Data S1, typing method not clear
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: variable/discrepant (last update: Dec. 28, 2020)Reports by D phenotype
Other RH phenotypes: RH:-23, 52, -52,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: NA (last update: Dec. 28, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant, see types or alleles (last update: Dec. 28, 2020)Detailed information
-
Daniels G et al. Br J Haematol (2013)
(review; Table I)
- Ab specificity: D (RH1)
- Number (auto- or allo-):
- Number listed as allo-: no new case detailed (listed as allo-anti-D)
- Number listed as auto-: NA
- Number of carriers of the allele assessed: NA
- DAT: NA
- Autologuous control: NA
- Elution: NA
- Autoadsorption: NA
- Titer: NA
- Was anti-LW excluded?: NA
- Other antibodies detected: NA
- Cross matches (with Ab and RBCs from different partial types): NA
- Transfusion history: NA
- Pregnancy history:
- Anti-D Ig history: NA
- Context: NA
- Hemolytic consequences: NA
- Comment: list of D variants associated with alloanti-D formation
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: few descriptions, in individuals of Caucasian descent, or compatible with such descent (last update: Dec. 28, 2020)Detailed reports
- 2 samples donors with weak D phenotype White, in German or Austrian population
- 1 sample donors with weak D phenotype White, in German or Austrian population
- 1 sample used for comparison referred by a Brazilian lab, Sao Paolo
- 1 sample? used for comparison referred by a UK lab from Lanarkshire, Scotland
- 2/10000 screening of D positive individuals Indian (West India)
- 8/60 samples with ambiguous D phenotype, including those from the population study of the same study Indian (West India)
- 8/430 among samples with ambigous D phenotype in the French population (Table S1)
- 2/353 samples referred for discrepant or weak D typing in the USA population
Allele or phenotype frequency
Structure mapping
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References
- Gassner C et al. RHD/CE typing by polymerase chain reaction using sequence-specific primers. Transfusion, 1997. [Citation] [RHeference]
- Legler TJ et al. RHD genotyping in weak D phenotypes by multiple polymerase chain reactions. Transfusion, 1998. [Citation] [RHeference]
- Maaskant-van Wijk PA et al. Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons. Transfusion, 1998. [Citation] [RHeference]
- Omi T et al. Isolation, characterization, and family study of DTI, a novel partial D phenotype affecting the fourth external loop of D polypeptides. Transfusion, 2002. [Citation] [RHeference]
- Westhoff CM et al. Rh complexities: serology and DNA genotyping. Transfusion, 2007. [Citation] [RHeference]
- Kulkarni S et al. Frequency of partial D in Western India. Transfus Med, 2008. [Citation] [RHeference]
- Daniels G et al. Variants of RhD--current testing and clinical consequences. Br J Haematol, 2013. [Citation] [RHeference]
- Fichou Y et al. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles. Transfusion, 2013. [Citation] [RHeference]
- Zacarias JM et al. Frequency of RHD variants in Brazilian blood donors from Parana State, Southern Brazil. Transfus Apher Sci, 2016. [Citation] [RHeference]
- S Vege et al. RHD Genotyping of Discrepant or Weak D Samples: Over a Year’s Experience. Transfusion, 2017. — Abstract — [RHeference]
- Takeuchi-Baba C et al. Production of RBC autoantibody mimicking anti-D specificity following transfusion in a patient with weak D Type 15. Transfusion, 2019. [Citation] [RHeference]
- Vege S et al. Impact of RHD genotyping on transfusion practice in Denmark and the United States and identification of novel RHD alleles. Transfusion, 2021. [Citation] [RHeference]
Last update: Dec. 28, 2020