Nucleotides: 579G>A; 1136C>T;

Amino acids: E193E; T379M;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

Extracellular position of one or more amino acid substitutions:

• none of the mutations are predicted to affect an extracellular amino acid

Splicing:

Unconventional prediction methods:

Reports by D phenotype

Other RH phenotypes: RH:

Serology with monoclonal anti-D

Antigen Density (Ag/RBC)

More phenotype data

Reports by CcEe phenotype

Reports by allele association

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Detailed reports

• 2/58 random donors carrying the allele (regardless of the allele in trans) Malian
• 1/316 (1 heterozygous with RHef00313, 1 with RHef00442) 316 (280 D positive and 36 D negative) donors were genotyped African descent (FY:-1,-2) in the French population
• 1/35 SCD patients with unexplained RH antibodies, explored by NGS sequencing in the Brazilian population (Sao Paolo)
• 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)

Allele or phenotype frequency

• 0.017 estimated haplotypes frequency Malian
• 0.008 allele frequency among 480 African American donors African American (in the USA population)
• 0.004 allele frequency among 140 SCD patients African American (in the USA population)
• 0.029 - 0.039 allele frequency from molecular typing of 101 random samples Dogon Malian