RHD*01W.1.2 - RHD*weak D type 1.2
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(V238M,V270G), RHD*712A,809G, RHD*712A,809G (weak D type 1.2), RHD*712G>A,809T>G, weak D type 1.2,
Molecular data
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: May 4, 2020)Reports by D phenotype
- Discrepant D phenotype (negative or positive depending on anti-D reagents and techniques)
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
- Weak D phenotype
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
- Very weak D phenotype
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce (last update: Jan. 8, 2021)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: May 4, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: rare descriptions, possible Western European descent (last update: May 4, 2020)Detailed reports
- 1/15446 first time donors with D negative phenotype, tested for D phenotype in immediate spin and IAT testing in the Canadian (Ontario) population, mainly White
- 2/25 among 25 donor and prenatal patient samples from different countries with discrepancies between targeted genotyping and serology
- 1 sample reported by a USA lab from Wisconsin
- 0/256 samples with RHD c.809T>G mutation (typical of RHef00238) in the French population (Western France)
- 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Goldman M et al. Identifying D-positive donors using a second automated testing platform. Immunohematology, 2013. [Citation] [RHeference]
- Garcia F et al. New RHD variant alleles. Transfusion, 2015. [Citation] [RHeference]
- Isa K et al. Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles. Vox Sang, 2016. [Citation] [RHeference]
- Anani WQ et al. Molecular characterization of three novel weak D type alleles with additional haplotype data on weak D Types 1.2 and 18. Transfusion, 2017. [Citation] [RHeference]
- Raud L et al. Weak D type 1, 2 and 3 subtype alleles are rare in the Western French population. Transfus Med, 2019. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 8, 2021