RHD*01W.18 - RHD*weak D type 18
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(R7W), RHD*19C>T, RHD*19T, RHD*19T (weak D type 18), weak D type 18,
Molecular data
Phenotype
Main D phenotype: weak D (last update: Aug. 9, 2020)Reports by D phenotype
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce (last update: Jan. 8, 2021)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 0 | 5 | 0 | 0 |
Ce | 3 | 0 | 0 | |
cE | 0 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Aug. 9, 2020)Detailed information
-
Pham BN et al. Immunohematology (2013)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 0
- Number listed as allo-:
- Number listed as auto-:
- Number of carriers of the allele assessed: 4
- DAT: NA
- Autologuous control: NA
- Elution: NA
- Autoadsorption: NA
- Titer: NA
- Was anti-LW excluded?: NA
- Other antibodies detected: NA
- Cross matches (with Ab and RBCs from different partial types): NA
- Transfusion history: ND
- Pregnancy history:
- Anti-D Ig history: ND
- Context: NA
- Hemolytic consequences: NA
- Comment:
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: several descriptions, in various populations, allele could be of Eastern Asian and/or Brazilian descent (last update: Aug. 9, 2020)Detailed reports
- 1/289 289 samples with ambiguous D phenotype (333 consecutive samples with ambiguous D phenotype studied but 44 were hybrid alleles, excluded from the study) in the French (Western France) population
- 4/45 45 samples referred for D typing discrepancies in the USA population (Table 2)
- 1/430 among samples with ambigous D phenotype in the French population (Table S1)
- 4/748 among 748 individuals with D anomaly (weak or discrepant D phenotype or anti-D in individuals with D positive phentoype), 459 had D variants "that could be named weak D" (including alleles RHef00313, RHef00317 and RHef00318, as well as RHef00197 and RHef00283), 138 had partial D, 65 had no variant, 86 were not persued further (two variant alleles or incomplete or pending analysis) in the French population
- 1/360 donors with atypical D phenotype (discrepancies or reactivity weaker than 3+) Brazilian
- 1/226 226 donors considered weak D phenotype, after ruling out partial D phenotypes by using 5 monoclonal anti-D Japanese
- 1 sample reported by a USA lab, Wisconsin
- 1/45 among 132479 donors screened for weak D phenotype in the northeastern Chinese Liaoning Province population
- 1/185 RH:–1,–4 or RH:–1,–5 recipients reported by a French lab
- 4 samples unrelated donors in the Brazilian population (Southern Brazil)
- 1 sample? reported by a German lab (CAB75731)
- 2 hemizygotes among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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Links
The Human RhesusBaseGenbank: CAB75731 KU195715 KP718114 AJ287289 AJ287290 AJ287291 AJ287292 AJ287293 AJ287294 AJ287295 AJ287296 AJ287297 AJ287298
Erythrogene
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
- Westhoff CM et al. Rh complexities: serology and DNA genotyping. Transfusion, 2007. [Citation] [RHeference]
- Le Maréchal C et al. Identification of 12 novel RHD alleles in western France by denaturing high-performance liquid chromatography analysis. Transfusion, 2007. [Citation] [RHeference]
- Flegel WA et al. D variants at the RhD vestibule in the weak D type 4 and Eurasian D clusters. Transfusion, 2009. [Citation] [RHeference]
- Pham BN et al. Molecular analysis of patients with weak D and serologic analysis of those with anti-D (excluding type 1 and type 2). Immunohematology, 2013. [Citation] [RHeference]
- Fichou Y et al. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles. Transfusion, 2013. [Citation] [RHeference]
- Arnoni CP et al. How do we identify RHD variants using a practical molecular approach? Transfusion, 2014. [Citation] [RHeference]
- Isa K et al. Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles. Vox Sang, 2016. [Citation] [RHeference]
- Anani WQ et al. Molecular characterization of three novel weak D type alleles with additional haplotype data on weak D Types 1.2 and 18. Transfusion, 2017. [Citation] [RHeference]
- Jérôme Babinet et al. Erratum à l’article : « Résumés des Posters » [Transfus. Clin. Biol. 24 (2017) 3S] Transfusion Clinique et Biologique, 2018. — Abstract — [RHeference]
- C Araujo et al. Serological and Molecular Characterization of Weak D Type 18 in Four Brazilian Families Transfusion, 2018. — Abstract — [RHeference]
- Zhang X et al. Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China. J Transl Med, 2019. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 8, 2021