RHD*01N.83
(ISBT table: RHD negative v4.0)
This entry is an hybrid RHD allele.
RHD*150C,178C,201A,203A,307C,702delG (RHD*01N.83), RHD*702delG,
Molecular data
Nucleotides:
150T>C; 178A>C; 201G>A; 203G>A; 307T>C; 702del1;
Amino acids: V50V; I60L; S67S; S68N; S103P; K235Rfs*11;
Hybrid allele encompassing at least one RHCE exon:
RHD-RHCE(2)-RHD(702delG)
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D negative (DEL excluded) (last update: July 28, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2, -3,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce (last update: Aug. 15, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: D negative, at risk for anti-D (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: not expected, see phenotype data
Reports
Summary: rare descriptions, in Asian individuals (including the Indian subcontinent), or compatible with such descent (last update: June 12, 2020)Detailed reports
- 1 sample RHD molecular screening of donors with D negative phenotype Asian, reported by an Italian lab
- 1/171 (heterozygous with RHef00448) donors with D negative phenotype, C and/or E positive Indian
- 1/200 donors with D negative phenotype (DEL phenotype excluded) Thai
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Matteocci A et al. Two novel RHD alleles encoding truncated, nonfunctional D polypeptides. Transfusion, 2018. [Citation] [RHeference]
- Kulkarni SS et al. RHD-Positive Alleles among D- C/E+ Individuals from India. Transfus Med Hemother, 2018. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Thongbut J et al. Comprehensive Molecular Analysis of Serologically D-Negative and Weak/Partial D Phenotype in Thai Blood Donors. Transfus Med Hemother, 2020. [Citation] [RHeference]
Last update: June 23, 2020