RHD*01W.17 - RHD*weak D type 17
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(R114W), RHD*340C>T, RHD*340T, RHD*340T (weak D type 17), weak D type 17,
Molecular data
Phenotype
Main D phenotype: variable/discrepant (last update: Aug. 9, 2020)Reports by D phenotype
Other RH phenotypes: RH:-48, -53,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Haplotype
Main CcEe phenotype association: CE? (last update: Aug. 15, 2020)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 0 | 1 | 0 | 0 |
Ce | 0 | 2 | 0 | |
cE | 0 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Aug. 9, 2020)Detailed information
-
Pham BN et al. Immunohematology (2013)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 0
- Number listed as allo-:
- Number listed as auto-:
- Number of carriers of the allele assessed: 1
- DAT: NA
- Autologuous control: NA
- Elution: NA
- Autoadsorption: NA
- Titer: NA
- Was anti-LW excluded?: NA
- Other antibodies detected: NA
- Cross matches (with Ab and RBCs from different partial types): NA
- Transfusion history: ND
- Pregnancy history:
- Anti-D Ig history: ND
- Context: NA
- Hemolytic consequences: NA
- Comment:
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: few descriptions, in various populations, allele could be of Eastern Asian and/or North African descent (last update: Aug. 9, 2020)Detailed reports
- 1 sample donors in the German population (Southwestern Germany), White
- 2/126 donors with D negative phenotype Korean (South Korea)
- 1/50 (1 donor and 0 patients) 50 samples (33 donors and 17 patients) with discrepant or weak D phenotyping in the Egyptian population
- 1/748 among 748 individuals with D anomaly (weak or discrepant D phenotype or anti-D in individuals with D positive phenotype), 459 had D variants "that could be named weak D" (including alleles RHef00313, RHef00317 and RHef00318, as well as RHef00197 and RHef00283), 138 had partial D, 65 had no variant, 86 were not persued further (two variant alleles or incomplete or pending analysis) in the French population
- 1/32 donors suspected to have weak D or partial D phenotypes sent to a reference laboratory Chinese (Zhejiang Han)
- 1/627 weak D phenotype (95% from patients, 5% from donors; 21,2% were identified as RHef00442 or RHef00446 by authors, "mostly (…) inconclusive serology consequent to recent transfusion") in the Belgian (Flanders) population
- 1/100 donors with weak D phenotype Australia
- 1/185 RH:–1,–4 or RH:–1,–5 recipients reported by a French lab
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Wagner FF et al. Weak D alleles express distinct phenotypes. Blood, 2000. [Citation] [RHeference]
- Luettringhaus TA et al. An easy RHD genotyping strategy for D- East Asian persons applied to Korean blood donors. Transfusion, 2006. [Citation] [RHeference]
- Flegel WA et al. How I manage donors and patients with a weak D phenotype. Curr Opin Hematol, 2006. [Citation] [RHeference]
- Flegel WA et al. D variants at the RhD vestibule in the weak D type 4 and Eurasian D clusters. Transfusion, 2009. [Citation] [RHeference]
- Schmid P et al. Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD. Transfusion, 2010. [Citation] [RHeference]
- Pham BN et al. Molecular analysis of patients with weak D and serologic analysis of those with anti-D (excluding type 1 and type 2). Immunohematology, 2013. [Citation] [RHeference]
- Abdelrazik AM et al. Combining serology and molecular typing of weak D role in improving D typing strategy in Egypt. Transfusion, 2013. [Citation] [RHeference]
- Van Sandt VS et al. RHD variants in Flanders, Belgium. Transfusion, 2015. [Citation] [RHeference]
- He J et al. Molecular basis and zygosity determination of D variants including identification of four novel alleles in Chinese individuals. Transfusion, 2015. [Citation] [RHeference]
- Srivastava K et al. The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens. Transfusion, 2016. [Citation] [RHeference]
- McGowan EC et al. Diverse and novel RHD variants in Australian blood donors with a weak D phenotype: implication for transfusion management. Vox Sang, 2017. [Citation] [RHeference]
- Jérôme Babinet et al. Erratum à l’article : « Résumés des Posters » [Transfus. Clin. Biol. 24 (2017) 3S] Transfusion Clinique et Biologique, 2018. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: Aug. 9, 2020