Reports by D phenotype

Other RH phenotypes: RH:-2, -3, 12,

Serology with monoclonal anti-D

Antigen Density (Ag/RBC)

More phenotype data

Reports by CcEe phenotype

Reports by allele association

Detailed information

Wang M et al. Transfus Med (2015) (study may overlap with 25960711)

• Ab specificity: D (RH1)
• Number (auto- or allo-): 1
• Number listed as allo-:
• Number listed as auto-:
• Number of carriers of the allele assessed:
• DAT:
• Autologuous control:
• Elution:
• Autoadsorption:
• Titer: 16 (with papain treated R2R2 RBCs)
• Was anti-LW excluded?:
• Other antibodies detected:
• Cross matches (with Ab and RBCs from different partial types):
• Transfusion history:
• Pregnancy history:
• Anti-D Ig history:
• Context: pregnant women with DEL phenotype
• Hemolytic consequences: no HDFN, peak bilirubin 108µmol/L
• Comment:

Detailed reports

• 4/8442 (3 with RHD-specific and 1 with RHCE-specific polymorphisms in intron 7) 8442 donors with D negative phenotype, screened for presence of the RHD gene in two surveys; 754 donors were C and/or E positive, the rest were ccee phenotype; 5 donors were revealed to be weakly D positive in the German population (Baden-Wurttemberg)
• 1/738 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 1 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 0 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the Austrian (state of Tyrol) population
• 0/104 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 0 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 0 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the Swiss (Bern and the canton of Bern) population
• 0/54 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 0 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 0 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the German (city of Braunschweig and eastern parts of Lower Saxony) population
• 1/400 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 0 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 1 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the German (states of Lower Saxony, Saxony- Anhalt, Thuringia, Oldenburg, and Bremen) population
• 0/71 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 0 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 0 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the Russian (Kirov Oblast) population
• 1/333 samples with D negative, but C and/or E positive phenotype, screened for RHD specific sequences (in the 5'UTR region, exon 3 and exon 10); 0 sample for allele listed as RHD-CE(4-7)-D and E positive phenotype, 1 samples for allele listed as RHD-CE(4-8)-D with C positive phenotype in the Slovenian population
• 1/448 448 donors with D negative phenotype, tested for the presence of RHD exon 10 in the Tunisian population
• 1/31200 consecutive donors with D negative phenotype, tested for presence of RHD intron 4, exon 7 and/or exon 10 in the Polish population
• 2/25370 donors with D negative phenotype, screened for RHD exons 3 or 7, plus 5 and 10 in the Swiss population (study may overlap with 24656493)
• 1/42306 42306 donors were screened, of which 165 had apparent D negative phenotype, of which 41 were DEL phenotype and characterized at the molecular level East and South-East China
• 4/2027 2027 donors with D negative phenotype, C and/or E positive, screened for RHD exons 4, 5 and 10 and for DEL phenotype in the Australian population
• 1/3526 donors with D negative phenotype Japanese
• 1/142 pregnant women with apparent D negative phenotype Han Chinese (study may overlap with 25960711)
• 1/1174 donors with D negative phenotype United States population (Los Angeles)
• 1/526 among donors with D negative phenotype, C and/or E positive tested for presence of the RHD gene in the Argentinean population (Northwestern Argentina)
• 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)

Allele or phenotype frequency

• 1/18036 (CI: 1/6678 - 1/66145) for allele with RHD-specific polymorphisms in intron 7 estimated allele frequency by testing 8442 donors with D negative phenotype, screened for presence of the RHD gene in two surveys; 754 donors were C and/or E positive, the rest were ccee phenotype; 5 donors were revealed to be weakly D positive in the German population (Baden-Wurttemberg)
• 1/45455 (CI: 1/8539 - 1/891266) for allele with RHCE-specific polymorphisms in intron 7 estimated allele frequency by testing 8442 donors with D negative phenotype, screened for presence of the RHD gene in two surveys; 754 donors were C and/or E positive, the rest were ccee phenotype; 5 donors were revealed to be weakly D positive in the German population (Baden-Wurttemberg)
• 1/31200 (CI: 1/6577 - 1/608187) estimated allele frequency in individuals with D negative phenotype in the Polish population
• 0.007 allele frequency among 140 SCD patients African American (in the USA population)
• 0.0 allele frequency among 480 African American donors African American (in the USA population)