RHD*01W.13 - RHD*weak D type 13<br /><small>(ISBT table: Weak D and Del v5.0)</small><br />

Molecular Data Phenotype Haplotype Alloimmunization Reports 2D diagram Structure Links References

RHD01W.13 - RHDweak D type 13
(ISBT table: Weak D and Del v5.0)

This entry is an RHD allele.

RHD(A276P), RHD*826C, RHD*826C (weak D type 13), RHD*826G>C, weak D type 13,

Download VCF file

Molecular data

Nucleotides: 826G>C;

Amino acids: A276P;

Hybrid allele encompassing at least one RHCE exon: no

Comments on the molecular basis:

Extracellular position of one or more amino acid substitutions:

none of the mutations are predicted to affect an extracellular amino acid
membrane localization: TM

Splicing:

Unconventional prediction methods:

Phenotype

Main D phenotype: weak D (last update: May 3, 2020)

Reports by D phenotype

Weak D phenotype
- ISBT classification

Other RH phenotypes: RH:

Serology with monoclonal anti-D

1 monoclonal IgG anti-D non-reactive with variant, out of 60 monoclonal IgG anti 22 IgM anti-D tested

Antigen Density (Ag/RBC)

946 Ag/RBC, derived from the results obtained with 59 of the 59 monoclonal IgG anti-D tested

More phenotype data

Rhesus Similarity Index

0.33 (derived from the results obtained with 59 of the 59 monoclonal IgG anti-D tested)

Haplotype

Main CcEe phenotype association: Ce (last update: Aug. 15, 2020)

Number of samples reported by haplotype
	ce	Ce	cE
ce	0	0	0
Ce		2	0
cE			0
CE

Reports by CcEe phenotype

with Ce

Main allele association:

Reports by allele association

Alloimmunization

Antibodies in carriers

Antibody specificity: D (RH1)

Summary: no published cases (last update: Nov. 17, 2019)

Detailed information

Antibodies in D negative recipients

Alloimmunization in recipients: expected to be possible, see phenotype data

Reports

Summary: exceptional description(s), in Austrian individuals (last update: May 3, 2020)

Detailed reports

0/161 random donors with weak D phenotype; DVI samples were excluded by serologic testing in the German population (Southwestern Germany), White (Table 6)
1/146 donors with weak D phenotype White, in the Austrian (Tyrol) population
0/270 donors with weak D phenotype White, in the German (Northern Germany) population

Allele or phenotype frequency

2D diagram

Structure mapping

Movement	Mouse Input	Touch Input
Rotation	Primary Mouse Button	Single touch
Translation	Middle Mouse Button or Ctrl+Primary	Triple touch
Zoom	Scroll Wheel or Second Mouse Button or Shift+Primary	Pinch (double touch)
Slab	Ctrl+Second	Not Available

Links

The Human RhesusBase
Genbank:
Erythrogene

References

International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
Wagner FF et al. Molecular basis of weak D phenotypes. Blood, 1999. [Citation] [RHeference]
Wagner FF et al. Weak D alleles express distinct phenotypes. Blood, 2000. [Citation] [RHeference]
Müller TH et al. PCR screening for common weak D types shows different distributions in three Central European populations. Transfusion, 2001. [Citation] [RHeference]
Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]

Last update: May 3, 2020

RHD*01W.13 - RHD*weak D type 13(ISBT table: Weak D and Del v5.0)