RHD*01W.9 - RHD*weak D type 9
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(A294P), RHD*880C, RHD*880C (weak D type 9), RHD*880G>C, weak D type 9,
Molecular data
Phenotype
Main D phenotype: weak D (last update: May 4, 2020)Reports by D phenotype
- Discrepant D phenotype (negative or positive depending on anti-D reagents and techniques)
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
- Weak D phenotype
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
- Very weak D phenotype
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
- D negative
- Negative by immediate spin, weakly positive with one or more anti-D by IAT
Other RH phenotypes: RH:-2,
- RH:-2 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Haplotype
Main CcEe phenotype association: cE? (last update: Jan. 8, 2021)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 0 | 1 | 1 | 0 |
Ce | 0 | 0 | 0 | |
cE | 2 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: May 4, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: rare descriptions, in individuals of Central European descent, or compatible with such descent (last update: May 4, 2020)Detailed reports
- 1/161 random donors with weak D phenotype; DVI samples were excluded by serologic testing in the German population (Southwestern Germany), White (Table 6)
- 0/146 donors with weak D phenotype White, in the Austrian (Tyrol) population
- 0/270 donors with weak D phenotype White, in the German (Northern Germany) population
- 1/31200 consecutive donors with D negative phenotype, tested for presence of RHD intron 4, exon 7 and/or exon 10 in the Polish population
- 1/15446 first time donors with D negative phenotype initially, tested for D phenotype in immediate spin and IAT testing in the Canadian (Ontario) population, mainly White
- 1/351 out of 351 prenatal patients with discrepant D phenotyping results (population tested 608486 patients) Canada
- 1/662 among 662 pregnant patients with apparent D negative phenotype, enroled for fetal genotyping in the Australian population
- 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Wagner FF et al. Molecular basis of weak D phenotypes. Blood, 1999. [Citation] [RHeference]
- Wagner FF et al. Weak D alleles express distinct phenotypes. Blood, 2000. [Citation] [RHeference]
- Müller TH et al. PCR screening for common weak D types shows different distributions in three Central European populations. Transfusion, 2001. [Citation] [RHeference]
- Orzińska A et al. RHD variants in Polish blood donors routinely typed as D-. Transfusion, 2013. [Citation] [RHeference]
- Goldman M et al. Identifying D-positive donors using a second automated testing platform. Immunohematology, 2013. [Citation] [RHeference]
- Clarke G et al. Resolving variable maternal D typing using serology and genotyping in selected prenatal patients. Transfusion, 2016. [Citation] [RHeference]
- Hyland CA et al. Non-invasive fetal RHD genotyping for RhD negative women stratified into RHD gene deletion or variant groups: comparative accuracy using two blood collection tube types. Pathology, 2017. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 8, 2021