RHD*01W.42 - RHD*weak D type 42
(ISBT table: Weak D and Del v5.0)
This entry is an RHD allele.
RHD(K409M), RHD*1226A>T, RHD*1226T, RHD*1226T (weak D type 42), weak D type 42,
Molecular data
Phenotype
Main D phenotype: variable/discrepant (last update: Dec. 28, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2,
- RH:-2 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: cE (last update: Jan. 8, 2021)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: allo-anti-D (last update: Dec. 28, 2020)Detailed information
-
St-Louis M et al. Immunohematology (2011)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 1 ("suspected anti-D")
- Number listed as allo-: 2
- Number listed as auto-: 3
- Number of carriers of the allele assessed: 17
- DAT: at least one patient with allo-anti-D had positive DAT
- Autologuous control: ND
- Elution: ND
- Autoadsorption: auto-adsorptions were performed, results not detailed
- Titer: ND
- Was anti-LW excluded?: ND
- Other antibodies detected: anti-G was not ruled out
- Cross matches (with Ab and RBCs from different partial types): ND
- Transfusion history: both patients with allo-anti-D had a history of transfusion(s)
- Pregnancy history:
- Anti-D Ig history: ND, probably none
- Context: ND
- Hemolytic consequences: ND
- Comment:
-
Denomme GA et al. Transfusion (2005)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 0
- Number listed as allo-:
- Number listed as auto-:
- Number of carriers of the allele assessed:
- DAT:
- Autologuous control:
- Elution:
- Autoadsorption:
- Titer:
- Was anti-LW excluded?:
- Other antibodies detected:
- Cross matches (with Ab and RBCs from different partial types):
- Transfusion history:
- Pregnancy history:
- Anti-D Ig history:
- Context:
- Hemolytic consequences:
- Comment: lists exposures to standard D antigen and patient blood management for several carriers
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: frequent descriptions, in Caucasian Canadians or compatible with Caucasian descent (last update: Dec. 28, 2020)Detailed reports
- 2/55 55 discrepant or weak D phenotypes among 33864 multiethnic patients (of African, Asian, Indoasian and European extraction) White, in the Canadian (Toronto) population
- 1/101 donors with weak D phenotype Danish
- 50 samples including 17/26 among 26 French Canadian with weak D phenotype or D positive phenotype and anti-D Caucasian, French Canadian
- 0/500 D positive donors originating from different regions of the province in the Canadian population
- 5/351 out of 351 prenatal patients with discrepant D phenotyping results (population tested 608486 patients) Canada
- 1/353 samples referred for discrepant or weak D typing in the USA population
- 1 hemizygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Denomme GA et al. Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti-D alloimmunization and prevention. Transfusion, 2005. [Citation] [RHeference]
- Christiansen M et al. Correlation between serology and genetics of weak D types in Denmark. Transfusion, 2008. [Citation] [RHeference]
- St-Louis M et al. Weak D type 42 cases found in individuals of European descent. Immunohematology, 2011. [Citation] [RHeference]
- Fichou Y et al. Extensive functional analyses of RHD splice site variants: Insights into the potential role of splicing in the physiology of Rh. Transfusion, 2015. [Citation] [RHeference]
- Clarke G et al. Resolving variable maternal D typing using serology and genotyping in selected prenatal patients. Transfusion, 2016. [Citation] [RHeference]
- S Vege et al. RHD Genotyping of Discrepant or Weak D Samples: Over a Year’s Experience. Transfusion, 2017. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
- Vege S et al. Impact of RHD genotyping on transfusion practice in Denmark and the United States and identification of novel RHD alleles. Transfusion, 2021. [Citation] [RHeference]
Last update: Jan. 8, 2021