RHD*384C
(ISBT table: not listed)
				This entry is an RHD allele.
						RHD(D128D), RHD*384C, RHD*384T>C, 
					
	
				Molecular data
						Nucleotides:
						384T>C; 
					
Amino acids: D128D;
						Hybrid allele encompassing at least one  RHCE  exon:
						no
					
						Comments on the molecular basis:
						
						Extracellular position of one or more amino acid substitutions: 
						
- Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.
 
						Splicing:
						
						Unconventional prediction methods:
						
Phenotype
Main D phenotype: unknown (last update: Nov. 17, 2019)Reports by D phenotype
Other RH phenotypes: RH:
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce? (last update: Jan. 8, 2021)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Nov. 17, 2019)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: unknown
Reports
Summary: exceptional description(s), in Africans or African descent (last update: Dec. 22, 2019)Detailed reports
- 1/58 random donors carrying the allele (regardless of the allele in trans) Malian
 - 1 or more among 829 samples African American (in the USA population)
 - 1 heterozygote among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
 
Allele or phenotype frequency
Structure mapping
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References
- Wagner FF et al. RHD allele distribution in Africans of Mali. BMC Genet, 2003. [Citation] [RHeference]
 - Reid ME et al. Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease. Blood Cells Mol Dis, 2014. [Citation] [RHeference]
 - Chun S et al. The synonymous nucleotide substitution RHD 1056C>G alters mRNA splicing associated with serologically weak D phenotype. J Clin Lab Anal, 2018. [Citation] [RHeference]
 - Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
 - Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
 
Last update: Jan. 8, 2021