RHD*939C
(ISBT table: not listed)
This entry is an RHD allele.
RHD(P313P), RHD(P313P) [RHD*939C], RHD*939C, RHD*939G>C,
Molecular data
Nucleotides:
939G>C;
Amino acids: P313P;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
- Silent or intronic mutations: none of the mutations are predicted to affect an extracellular amino acid.
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: Dec. 28, 2020)Reports by D phenotype
- Weak D phenotype
- Mixed field
Other RH phenotypes: RH:-3,
- RH:-3 inferred from the reported RHCE phenotypes of the carriers
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce? (last update: Dec. 28, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: no published cases (last update: Dec. 28, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: exceptional description(s), in the USA population (last update: Dec. 28, 2020)Structure mapping
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References
- S Vege et al. RHD Genotyping of Discrepant or Weak D Samples: Over a Year’s Experience. Transfusion, 2017. — Abstract — [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Vege S et al. Impact of RHD genotyping on transfusion practice in Denmark and the United States and identification of novel RHD alleles. Transfusion, 2021. [Citation] [RHeference]
Last update: Dec. 28, 2020