RHD*01N.01
(ISBT table: RHD negative v4.0)
This entry is an RHD allele.
RHD deletion, RHD deletion (RHD*01N.01),
Molecular data
Nucleotides:
exon deletion(s);
Amino acids: exon deletion(s) [1, 2, 3, 4, 5, 6, 7, 8, 9, 10];
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
- Explanation of how the RHD deletion occurred
- RHD-specific miRNA expression level quantification compared to RHef00122
- some characterized, some assumed, all occurrences are listed here
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D negative (DEL excluded) (last update: Aug. 9, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2, -3, -4, -5,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce is the most frequent association, all associations are possible (last update: June 23, 2020)| ce | Ce | cE | CE | |
|---|---|---|---|---|
| ce | 5357 | 1053 | 1709 | 0 |
| Ce | 51 | 173 | 3 | |
| cE | 608 | 22 | ||
| CE | 0 |
Reports by CcEe phenotype
- with ce 1252 samples
- with cE 2 samples
- with Ce 6 samples
- with Ccee 201 samples
- with CcEe 37 samples
- with ccEe 64 samples
- with CCEe 1 sample
- with cCEE 22 samples
157 samples
1192 samples
103 samples
72 samples
875 samples
108 samples (some samples may overlap with
514 samples (some samples may overlap with
25 samples
58 samples
4 samples
0 samples (Figure 2; presented as a general association, no sample count)
992 samples
5 samples (in trans to other alleles)
3 samples
1 sample (in trans to other alleles)
598 samples
4 samples
27 samples
8 samples
4 samples
1 sample (some samples may overlap with
5 samples (some samples may overlap with
267 samples
3 samples
63 samples
94 samples
2 samples
127 samples
39 samples
17 samples (some samples may overlap with
84 samples (some samples may overlap with
149 samples (99 homozygous, 50 heterozygous with various alleles)
1 sample
6 samples (in trans to other alleles)
4 samples
6 samples
3 samples
117 samples
5 samples
1 sample (in trans to other alleles)
148 samples
33 samples
25 samples
11 samples
18 samples
1342 samples
3 samples (some samples may overlap with
22 samples (some samples may overlap with
20 samples (19 homozygous, 1 heterozygous with another allele)
23 samples
2 samples
Reports by allele association
- RHCE*ce(48C,733G,1006T) (RHCE*ce.20.03)
- RHCE*01
- RHCE*01.01 (RHCE*48C)
- RHCE*ceAG (RHCE*01.06.01)
- RHCE*01.20.01 (RHCE*733G)
- RHCE*01.20.02 (RHCE*ce48,733)
- RHCE*01.20.01 (RHCE*733G) or RHCE*01
- RHCE*02 or RHCE*03
- RHCE*02 or RHCE*01
- RHCE*02 or RHCE*ceTI
- RHCE*02 or RHCE*ce733G
- RHCE*ceAG or RHCE*ce733G
- RHCE*01.01 or RHCE*ce479G, 733G
- RHCE*01 or RHCE*01.01
- RHCE*Ce or RHCE*ce(1123A)
- RHCE*ce or RHCE*ce(285T)
- RHCE*Ce or RHCE*ceLOCR
- RHCE*Ce or RHCE*ceSL.02
- RHCE*Ce or Duplication RHCE*ce
- RHCE*Ce.26 or RHCE*ce
- RHCE*cEEW or RHCE*ce
- RHCE*Ce(436T) or RHCE*ce
- RHCE*Ce(462T) or RHCE*ce
- RHCE*Ce(1153C) or RHCE*ce
- RHCE*Ce−D(2)−Ce or RHCE*ce
- RHCE*CeN.08 or RHCE*ce
- RHCE*CeRN or RHCE*ce
- RHCE*cE or RHCE*ce
- RHCE*cE(92C) or RHCE*Ce
- RHCE*cE(281C,282T) or RHCE*Ce
- RHCE*cE(341A) or RHCE*ce
- RHCE*cE(697G) or RHCE*ce
- RHCE*02
- RHCE*Ce or RHCE*ce.01
- RHCE*03
- RHCE*CeCW or RHCE*ce
- RHCE*ceVS.01 or RHCE*ceCF
- RHCE*ceTI or RHCE*ceAG
- RHCE*03 or RHCE*01
- RHCE*ceAR or RHCE*ce
- RHCE*ceAR or RHCE*ceVS.03(609A)
- RHCE*ceVS.02(900T) or RHCE*ce
- RHCE*ceVS.04 or RHCE*ce
- RHCE*ceVS.04 or RHCE*ceAG
- RHCE*DAR3.1(31T) or RHCE*ceCF
- RHCE*ceCF or RHCE*ce.16
- RHCE*ceVS.02 or RHCE*ce
- RHCE*ce or RHCE*ceAG
- RHCE*ce.01 or RHCE*ce
- RHCE*ce.01 or RHCE*ce.01(105T)
- RHCE*ce.01 or RHCE*ceAG
- RHCE*ce.01(520A) or RHCE*ce.01
- RHCE*ce.01 or RHCE*ceVS.01
- RHCE*cE.03.02 or RHCE*ce
- RHCE*ce or RHCE*Ce(117A)
- RHCE*ce or RHCE*CeCX
- RHCE*ce or RHCE*ceVS.02
- RHCE*ce or RHCE*ceVS.01
- RHCE*ceVS.01 or RHCE*ce−D(9)−ce
- RHCE*ceVS.01 or RHCE*ceBI
- RHCE*ceAG.02 or RHCE*ceBI
- RHCE*ceCF or RHCE*ce
- RHCE*ceVS.02 or RHCE*ceVS.03
- RHCE*ceAG or RHCE*ceTI
- RHCE*ceEK or RHCE*ceTI
- RHCE*ce.10.02
- RHCE*ce.35
- RHCE*ceCF
- RHCE*ceHAR
- RHCE*ceVS.01(545G)
- RHCE*ce(234T)
- RHCE*ce(335+1A)
- RHCE*ce(361del2)
- RHCE*02 or RHCE*ceAG
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: D negative, at risk for anti-D (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: not expected, see phenotype data
Reports
Summary: main basis for D negative phenotype, described in all populations (last update: June 12, 2020)Detailed reports
- 26/28 samples donors with D negative phenotype in the Australian population
- 64/102 + 4/6 102 samples with D negative phenotype by IAT (118 D negative among 41.921 first time donors, DNA was available for 95; 7 D negative pregnant women), 76 were true D negative and 26 DEL phenotypes in the Chinese population, Shenzen area (96% Chinese Han) (6 samples) (102 samples)
- 150/204 donors with D negative phenotype Taiwanese
- 108/156 donors with D negative phenotype Taiwanese
- 185/294 D negative Taiwan Chinese
- 46/74 donors with D negative phenotype (adsorption-elution was not performed) Chinese Han
- 196/264 samples (or 459/528 alleles) donors with D negative phenotype Korean
- 94/126 donors with D negative phenotype Korean, South Korea
- 129/163 donors with D negative phenotype in the Chinese population, reported by a Shanghai lab
- 2423/2427 among 3 first-time donors without D expression but with amplification of RHD exons 4, 7, and 10 whithin 44,743 donors tested in the Austrian population, Upper Austria
- 59/110 random individuals with D negative phenotype Congolese, city of Brazzaville
- 84/733 donors with D negative phenotype Chinese, Shanghai
- 12/60 (5/21 donors, heterozygous with RHef00058; 7/39 patients, 6 heterozygous with RHef00058, 1 with RHef00672) among 60 individuals (21 donors, 39 patients) phenotyped as RH:54 and/or submitted for investigation to determine the RH genotype in the USA population (inferred African American)
- 217/239 among 2007 unrelated donors, 239 phenotyped as D negative were tested for RHD Intron 4 and Exon 10 in the Brazilian population, mainly racially mixed non-white skin color individuals, Sao Paulo
- 11/11 random donors with D negative phenotype included for the development of a genotyping assay in the Dutch population
- 9/430 among samples with ambigous D phenotype in the French population (Table S1)
- 39/39 among 308 donors (269 D positive, 39 D negative phenotype) who underwent molecular analysis in the Tunisian population
- 31137/31200 consecutive donors with D negative phenotype, tested for presence of RHD intron 4, exon 7 and/or exon 10 in the Polish population
- 52 alleles in 226 patients SCD children systematically genotyped in an alloimmunization study in the USA population, Philadelphia
- 24/316 316 (280 D positive and 36 D negative) donors were genotyped African descent (FY:-1,-2) in the French population
-
218/2000 among 2000 random donors (223 typed D negative), genotyped by amplifying RHD exons through 7 and 9 in the Tunisian population
(study may overlap with
25369614 ) - 0/127 (at the homozygous state) the cohort was composed of 77 Tswa from Congo, 36 Biaka from Central African Republic, 14 Mbuti from Democratic Republic of the Congo Pygmoid Central African
- 3/220 (at the homozygous state) the cohort was composed of 164 Teke-Congolese (ethnic groups: 60 Akwa, 52 Mbochi, 52 Kuyu) from Congo, 19 Mandenka from Senegal, 25 Yoruba from Nigeria, 12 Bantu from Kenya Nonpygmoid Central African
- 1685/2493 (homozyguous) donors with apparent D negative phenotype (108/2493 were in fact weak D or DEL) Han Chinese (Shanxi Province, Central China)
-
25250/25370 donors with D negative phenotype, screened for RHD exons 3 or 7, plus 5 and 10 in the Swiss population
(study may overlap with
24656493 ) - 1287/1314 samples with apparent D negative phenotype White Argentineans
- 4/48 (and several hemizygous samples, according to RHD zygosity determination) among 48 SCD patients with RH antibodies despite antigen-matched transfusion protocols African Brazilian
- 32/35 donors with D negative phenotype who underwent molecular analysis in the Tunisian population
- 3091/3526 donors with D negative phenotype (homozygous for RHef00446) Japanese
- 288/298 pregnant D negative women who underwent non-invasive fetal RHD detection in the Argentinean population (Rosario)
- 55/400 among random blood and bone marrow donors genotyped for RHD in the Brazilian population (Parana state, Southern Brazil)
- 79/110 among members of the RhD-negative club Korean
- 20/35 samples were hemizygous SCD patients with unexplained RH antibodies, explored by NGS sequencing in the Brazilian population (Sao Paolo)
- 12/200 (heterozygous with RHef00442) D positive donors tested by MPLA Chinese, Southern Han
- 127/200 (+61 hemizygous) donors with D negative phenotype, tested by MPLA Chinese, Southern Han
- 74/95 donors with apparent D negative phenotype Korean
- 647/662 among 662 pregnant patients with apparent D negative phenotype, enroled for fetal genotyping Turkish (in the Australian population)
- 118/171 (homozygous, +51 heterozygous with another silent allele) donors with D negative phenotype, C and/or E positive Indian
- 1115/1174 donors with D negative phenotype United States population (Los Angeles)
- 83/92 donors with apparent D negative phenotype, C and/or E positive Bosnia Herzegovina
- 55/61 donors with apparent D negative phenotype, C and/or E positive Serbia
- 425/526 among donors with D negative phenotype, C and/or E positive, tested for presence of the RHD gene in the Argentinean population (Northwestern Argentina)
- 1301/1403 1043 donors with D negative phenotype among 10417 random donors, were screened for RHD gene in the Brazilian population, Sao Paolo
- 256/517 in a population of 67428 random donors, 8042 had D negative phenotype, among those, 517 were C and/or E phenotype and were screened for RHD gene in the Brazilian population (Sao Paolo)
- 78/117 among 132479 donors screened, 117 had D negative phenotype in the northeastern Chinese Liaoning Province population
- 88/129 (in trans with various alleles) donors with weak D phenotype Thai
- 150/200 (homozygous) donors with D negative phenotype (DEL phenotype excluded) Thai
- 265/310 donors with D negative phenotype, C and/or E positive in the Italian population
- 10 homozygotes and 189 hemizygotes among 278 samples selected for the development of nonspecific quantitative next-generation sequencing. (non-random samples, may have been reported in other studies)
Allele or phenotype frequency
- 0.14 estimated haplotype frequency Malian
- 92.9 calculated allele frequency in individuals with D negative phenotype in the Chinese population (Shanghai)
- 1/22 (CI: 1/30 - 1/17) (for RHef00446 with RHCE:2,-3,4,5 or RH:2,3,4,5 phenotypes only) estimated allele frequency in donors with D negative phenotype United States population (Los Angeles)
- 0.59 - 0.91 estimated frequency in donors with apparent D negative phenotype (including DEL) Korean (South Korea)
- 0.040831 estimated allele frequency in the Chinese population (Shenzen area, 96% Chinese Han)
- 0.199 allele frequency from molecular typing of 101 random samples Dogon Malian
- 0.769608 estimated allele frequency in individuals with D negative phenotype in the Chinese population (Shenzen area, 96% Chinese Han)
- 0.75685 theoretical allele frequency in individuals with D negative phenotype Congolese (from the city of Brazzaville)
- 0.014 allele frequency among 140 SCD patients African American (in the USA population)
- 0.035 allele frequency among 480 African American donors African American (in the USA population)
- 0.147 allele frequency from molecular typing of 46 random samples Fulani Malian
- 0.433 frequency of the association with dce haplotype in donors homozygous for RHef00446 Japanese
- 0.527 frequency of the association with dcE haplotype in donors homozygous for RHef00446 Japanese
- 0.00244 calculated genotype frequency of homozygous RHef00446 in the northeastern Chinese Liaoning Province population
- 0.04937 calculated allele frequency in the northeastern Chinese Liaoning Province population
Structure mapping
| Movement | Mouse Input | Touch Input | ||
|---|---|---|---|---|
| Rotation | Primary Mouse Button | Single touch | ||
| Translation | Middle Mouse Button or Ctrl+Primary | Triple touch | ||
| Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
| Slab | Ctrl+Second | Not Available |
References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Colin Y et al. Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis. Blood, 1991. [Citation] [RHeference]
- Arce MA et al. Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals. Blood, 1993. [Citation] [RHeference]
- Hyland CA et al. Three unrelated Rh D gene polymorphisms identified among blood donors with Rhesus CCee (r'r') phenotypes. Blood, 1994. [Citation] [RHeference]
- Wagner FF et al. RHD gene deletion occurred in the Rhesus box. Blood, 2000. [Citation] [RHeference]
- Shao CP et al. Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese. Vox Sang, 2002. [Citation] [RHeference]
- Wagner FF et al. The DAU allele cluster of the RHD gene. Blood, 2002. [Citation] [RHeference]
- Peng CT et al. Molecular basis for the RhD negative phenotype in Chinese. Int J Mol Med, 2003. [Citation] [RHeference]
- Lee YL et al. Analysis of RHD genes in Taiwanese RhD-negative donors by the multiplex PCR method. J Clin Lab Anal, 2003. [Citation] [RHeference]
- Wagner FF et al. RHD allele distribution in Africans of Mali. BMC Genet, 2003. [Citation] [RHeference]
- Shao CP et al. A new hybrid RHD-positive, D antigen-negative allele. Transfus Med, 2004. [Citation] [RHeference]
- Chen JC et al. RHD 1227A is an important genetic marker for RhD(el) individuals. Am J Clin Pathol, 2004. [Citation] [RHeference]
- Kim JY et al. Molecular characterization of D- Korean persons: development of a diagnostic strategy. Transfusion, 2005. [Citation] [RHeference]
- Xu Q et al. Systemic analysis and zygosity determination of the RHD gene in a D-negative Chinese Han population reveals a novel D-negative RHD gene. Vox Sang, 2005. [Citation] [RHeference]
- Luettringhaus TA et al. An easy RHD genotyping strategy for D- East Asian persons applied to Korean blood donors. Transfusion, 2006. [Citation] [RHeference]
- Polin H et al. Effective molecular RHD typing strategy for blood donations. Transfusion, 2007. [Citation] [RHeference]
- Ye LY et al. Molecular and family analyses revealed two novel RHD alleles in a survey of a Chinese RhD-negative population. Vox Sang, 2007. [Citation] [RHeference]
- Touinssi M et al. Molecular analysis of inactive and active RHD alleles in native Congolese cohorts. Transfusion, 2009. [Citation] [RHeference]
- Ye L et al. Molecular bases of unexpressed RHD alleles in Chinese D- persons. Transfusion, 2009. [Citation] [RHeference]
- Westhoff CM et al. DIIIa and DIII Type 5 are encoded by the same allele and are associated with altered RHCE*ce alleles: clinical implications. Transfusion, 2010. [Citation] [RHeference]
- Chen Q et al. Molecular basis of weak D and DEL in Han population in Anhui Province, China. Chin Med J (Engl), 2012. [Citation] [RHeference]
- Cruz BR et al. RHD alleles in Brazilian blood donors with weak D or D-negative phenotypes. Transfus Med, 2012. [Citation] [RHeference]
- Chou ST et al. High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors. Blood, 2013. [Citation] [RHeference]
- Granier T et al. A comprehensive survey of both RHD and RHCE allele frequencies in sub-Saharan Africa. Transfusion, 2013. [Citation] [RHeference]
- O'Suoji C et al. Alloimmunization in sickle cell anemia in the era of extended red cell typing. Pediatr Blood Cancer, 2013. [Citation] [RHeference]
- Westhoff CM et al. RHCE*ceMO is frequently in cis to RHD*DAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance. Transfusion, 2013. [Citation] [RHeference]
- Daniels G et al. Variants of RhD--current testing and clinical consequences. Br J Haematol, 2013. [Citation] [RHeference]
- Ouchari M et al. [System RH: screening of partials D with RHD/RHCE hybrid gene]. Transfus Clin Biol, 2013. [Citation] [RHeference]
- Orzińska A et al. RHD variants in Polish blood donors routinely typed as D-. Transfusion, 2013. [Citation] [RHeference]
- Fichou Y et al. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles. Transfusion, 2013. [Citation] [RHeference]
- Haer-Wigman L et al. RHD and RHCE variant and zygosity genotyping via multiplex ligation-dependent probe amplification. Transfusion, 2013. [Citation] [RHeference]
- Lejon Crottet S et al. Serologic and molecular investigations of DAR1 (weak D Type 4.2), DAR1.2, DAR1.3, DAR2 (DARE), and DARA. Transfusion, 2013. [Citation] [RHeference]
- Ouchari M et al. RHD alleles in the Tunisian population. Asian J Transfus Sci, 2013. [Citation] [RHeference]
- Costa S et al. RHD alleles and D antigen density among serologically D- C+ Brazilian blood donors. Transfus Med, 2014. [Citation] [RHeference]
- Jakobsen MA et al. A case of high-titer anti-D hemolytic disease of the newborn in which late onset and mild course is associated with the D variant, RHD-CE(9)-D. Transfusion, 2014. [Citation] [RHeference]
- Reid ME et al. Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease. Blood Cells Mol Dis, 2014. [Citation] [RHeference]
- Wang QP et al. An investigation of secondary anti-D immunisation among phenotypically RhD-negative individuals in the Chinese population. Blood Transfus, 2014. [Citation] [RHeference]
- Ye SH et al. A comprehensive investigation of RHD polymorphisms in the Chinese Han population in Xi'an. Blood Transfus, 2014. [Citation] [RHeference]
- Gowland P et al. Molecular RHD screening of RhD negative donors can replace standard serological testing for RhD negative donors. Transfus Apher Sci, 2014. [Citation] [RHeference]
- Crottet SL et al. Implementation of a mandatory donor RHD screening in Switzerland. Transfus Apher Sci, 2014. [Citation] [RHeference]
- Trucco Boggione C et al. Molecular structures identified in serologically D- samples of an admixed population. Transfusion, 2014. [Citation] [RHeference]
- Kappler-Gratias S et al. Systematic RH genotyping and variant identification in French donors of African origin. Blood Transfus, 2014. [Citation] [RHeference]
- Ogasawara K et al. Molecular basis for D- Japanese: identification of novel DEL and D- alleles. Vox Sang, 2015. [Citation] [RHeference]
- Ba A et al. RH diversity in Mali: characterization of a new haplotype RHD*DIVa/RHCE*ceTI(D2). Transfusion, 2015. [Citation] [RHeference]
- Sippert E et al. Variant RH alleles and Rh immunisation in patients with sickle cell disease. Blood Transfus, 2015. [Citation] [RHeference]
- Kacem N et al. Paternal RHD zygosity determination in Tunisians: evaluation of three molecular tests. Blood Transfus, 2015. [Citation] [RHeference]
- Stegmann TC et al. Frequency and characterization of known and novel RHD variant alleles in 37 782 Dutch D-negative pregnant women. Br J Haematol, 2016. [Citation] [RHeference]
- Zacarias JM et al. Frequency of RHD variants in Brazilian blood donors from Parana State, Southern Brazil. Transfus Apher Sci, 2016. [Citation] [RHeference]
- Seo MH et al. An effective diagnostic strategy for accurate detection of RhD variants including Asian DEL type in apparently RhD-negative blood donors in Korea. Vox Sang, 2016. [Citation] [RHeference]
- Srivastava K et al. The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens. Transfusion, 2016. [Citation] [RHeference]
- Chou ST et al. Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia. Blood Adv, 2017. [Citation] [RHeference]
- Thongbut J et al. RHD-specific microRNA for regulation of the DEL blood group: integration of computational and experimental approaches. Br J Biomed Sci, 2017. [Citation] [RHeference]
- Hyland CA et al. Non-invasive fetal RHD genotyping for RhD negative women stratified into RHD gene deletion or variant groups: comparative accuracy using two blood collection tube types. Pathology, 2017. [Citation] [RHeference]
- Ji YL et al. RHD genotype and zygosity analysis in the Chinese Southern Han D+, D- and D variant donors using the multiplex ligation-dependent probe amplification assay. Vox Sang, 2017. [Citation] [RHeference]
- Boggione CT et al. Genotyping approach for non-invasive foetal RHD detection in an admixed population. Blood Transfus, 2017. [Citation] [RHeference]
- Dezan MR et al. RHD and RHCE genotyping by next-generation sequencing is an effective strategy to identify molecular variants within sickle cell disease patients. Blood Cells Mol Dis, 2017. [Citation] [RHeference]
- Kulkarni SS et al. RHD-Positive Alleles among D- C/E+ Individuals from India. Transfus Med Hemother, 2018. [Citation] [RHeference]
- Dezan MR et al. Evaluation of the applicability and effectiveness of a molecular strategy for identifying weak D and DEL phenotype among D- blood donors of mixed origin exhibiting high frequency of RHD*Ψ. Transfusion, 2018. [Citation] [RHeference]
- Dezan MR et al. High frequency of variant RHD genotypes among donors and patients of mixed origin with serologic weak-D phenotype. J Clin Lab Anal, 2018. [Citation] [RHeference]
- Kim B et al. Application of Multiplex Ligation-Dependent Probe Amplification Assay for Genotyping Major Blood Group Systems Including DEL Variants in the D-Negative Korean Population. Ann Lab Med, 2018. [Citation] [RHeference]
- de Paula Vendrame TA et al. Characterization of RHD alleles present in serologically RHD-negative donors determined by a sensitive microplate technique. Vox Sang, 2019. [Citation] [RHeference]
- Guzijan G et al. Implementation of Molecular RHD Typing at Two Blood Transfusion Institutes from Southeastern Europe. Transfus Med Hemother, 2019. [Citation] [RHeference]
- Zhang X et al. Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China. J Transl Med, 2019. [Citation] [RHeference]
- Perez-Alvarez I et al. RHD genotyping of serologic RhD-negative blood donors in a hospital-based blood donor center. Transfusion, 2019. [Citation] [RHeference]
- Izaskun Apraiz et al. Performance Evaluation Study of ID RHD XT as a Molecular Tool for RHD Gene Screening in Pooled Blood Samples of Serologically D− C/E+ Donors Transfusion, 2019. — Abstract — [RHeference]
- Trucco Boggione C et al. Characterization of RHD locus polymorphism in D negative and D variant donors from Northwestern Argentina. Transfusion, 2019. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
- Thongbut J et al. Comprehensive Molecular Analysis of Serologically D-Negative and Weak/Partial D Phenotype in Thai Blood Donors. Transfus Med Hemother, 2020. [Citation] [RHeference]
- Stef M et al. RH genotyping by nonspecific quantitative next-generation sequencing. Transfusion, 2020. [Citation] [RHeference]
Last update: Jan. 14, 2021