RHD*01EL.35 (obsolete) - RHD*DEL35 (obsolete)
(ISBT table: weak D and Del v5.0)
This entry is not counted as an allele.
RHD c.802-46_802- 42delTCTC, RHD(IVS5-38_-41delCTCT), RHD(IVS5-38del tctc), RHD(IVS5-38del4), RHD(IVS5-41delCTCT), RHD*802-38delTCTC, RHD*802-38delTCTC (IVS5-41delCTCT, DEL35),
Molecular data
Nucleotides:
intronic 802>;
Amino acids: 0;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
- described as an allele after anti-D immunization in a D negative patient detected 8 days after receiving proband's RBCs, anti-LW was ruled out, recipient DAT was negative, no hemolytic reaction or recuded RBC increment had occurred after the transfusion, one year later anti-D was confirmed with titer 128 by gel card and 64 by tube IAT; no other mutation in all 10 exons and flanking intron regions to explain phenotype
- is a polymorphism associated with several alleles, including RHef00442 and RHef00604
- see also "Additional comments" section on the RhesusBase http://www.rhesusbase.info/RHDRHD(IVS5-38deltctc).htm
- "Intron polymorphism"; "frequently observed in normal D phenotypes - obsolete", not considered an allele by ISBT anymore
- allele listed as a "variant of reported ISBT allele designation RHD*01N.58" RHef00496
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: NA (last update: Aug. 30, 2020)Reports by D phenotype
Other RH phenotypes: RH:-2, -3, -4,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: Ce (last update: Aug. 15, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: NA, NA (last update: Aug. 25, 2020)Detailed reports
- 4 samples DEL samples Austrian Caucasian
- 1 sample (heterozygous with RHef00442) Tibetan
- 20/174 174 random donor samples tested had IVS5-38del regardless of other associated mutations German
-
1/46,756 first time donors with D negative phenotype, tested for RHD exon 7 and adsorption-elution with a polyclonal anti-D in the German population (Northern)
(overlaps with
999999913 ; some samples may overlap with full publications) (overlaps with999999988 ; some samples may overlap with full publications) - 1/1174 donors with D negative phenotype United States population (Los Angeles)
Allele or phenotype frequency
Structure mapping
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References
- International Society of Blood Transfusion et al. International Society of Blood Transfusion (ISBT) allele table Online ressource, 1935. — Online ressource — [RHeference]
- Körmöczi GF et al. A comprehensive analysis of DEL types: partial DEL individuals are prone to anti-D alloimmunization. Transfusion, 2005. [Citation] [RHeference]
- Wagner T et al. Anti-D immunization by DEL red blood cells. Transfusion, 2005. [Citation] [RHeference]
- Wei Qing et al. Random survey for RH allele polymorphism among 50 native Tibetans. Open Access Repositorium of the University of Ulm (Germany), 2006. — Thesis — [RHeference]
- von Zabern I et al. IVS5-38del4 deletion in the RHD gene does not cause a DEL phenotype: relevance for RHD alleles including DFR-3. Transfusion, 2007. [Citation] [RHeference]
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
- Wagner FF et al. RHD PCR of blood donors in Northern Germany: use of adsorption/elution to determine D antigen status Vox Sanguinis, 2012. — Abstract — [RHeference]
- F F Wagner et al. Single Adsorption / Elution with Anti-D May Be Insufficient to Determine the D Antigen Status of Very Weak DEL Alleles Transfusion, 2012. — Abstract — [RHeference]
- Perez-Alvarez I et al. RHD genotyping of serologic RhD-negative blood donors in a hospital-based blood donor center. Transfusion, 2019. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: Jan. 2, 2021