D negative - phenotypic description
(ISBT table: not listed)
This entry is a phenotypic characterization.
D negative - phenotypic description,
Phenotype
Main D phenotype: D negative (last update: May 4, 2020)Reports by D phenotype
Other RH phenotypes: RH:
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce is the more frequent association, but all combinations are possible (last update: May 4, 2020)ce | Ce | cE | CE | |
---|---|---|---|---|
ce | 27 | 5 | 34 | 0 |
Ce | 2 | 6 | 1 | |
cE | 17 | 0 | ||
CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: NA
Reports
Summary: NA, NA (last update: Aug. 25, 2020)Detailed reports
- 92/130 unrelated donors Japanese
- 15441/15446 first time donors with D negative phenotype, tested for D phenotype in immediate spin and IAT testing in the Canadian population, mainly White, Ontario
- 2952/3019 donors with D negative phenotype initially, found to have D antigen expression in the Indian population
- 16/172 samples referred with discrepant or weak D typing, or discrepancies with previous typings, or anti-D in individuals with D positive individuals in the Indian population
Allele or phenotype frequency
Structure mapping
Movement | Mouse Input | Touch Input | ||
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Rotation | Primary Mouse Button | Single touch | ||
Translation | Middle Mouse Button or Ctrl+Primary | Triple touch | ||
Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
Slab | Ctrl+Second | Not Available |
References
- Avent ND et al. Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the RHD gene. Blood, 1997. [Citation] [RHeference]
- Okuda H et al. The RHD gene is highly detectable in RhD-negative Japanese donors. J Clin Invest, 1997. [Citation] [RHeference]
- Goldman M et al. Identifying D-positive donors using a second automated testing platform. Immunohematology, 2013. [Citation] [RHeference]
- Fichou Y et al. Molecular basis of weak D expression in the Indian population and report of a novel, predominant variant RHD allele. Transfusion, 2018. [Citation] [RHeference]
- Floch A et al. Comment from Rheference Online ressource, 2020. — Online ressource — [RHeference]
Last update: Aug. 25, 2020