partly characterized RHD*04 (DIV) (partly characterized or subtypes not separated)
(ISBT table: not listed)
This entry is partly characterized.
DIV - partly characterized or subtypes not separated,
Molecular data
Nucleotides:
Amino acids:
Hybrid allele encompassing at least one RHCE exon:
NA
Comments on the molecular basis:
- subtypes not separated
- RHef00071 and RHef00068 not separated
- RHef00069, RHef00070 and RHef00071 not separated
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: variable/discrepant (last update: May 2, 2020)Reports by D phenotype
Other RH phenotypes: RH:
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: NA (last update: Dec. 9, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant, see types or alleles (last update: Aug. 25, 2020)Detailed information
-
Sandler SG et al. Obstet Gynecol (2012)
- Ab specificity: D (RH1)
- Number (auto- or allo-): 1
- Number listed as allo-:
- Number listed as auto-:
- Number of carriers of the allele assessed:
- DAT: MD
- Autologuous control: MD
- Elution: MD
- Autoadsorption: MD
- Titer: MD
- Was anti-LW excluded?: MD
- Other antibodies detected: MD
- Cross matches (with Ab and RBCs from different partial types): MD
- Transfusion history: unknown
- Pregnancy history:
- Anti-D Ig history: none received
- Context: pregnancy
- Hemolytic consequences: MD
- Comment:
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: NA, NA (last update: Aug. 25, 2020)Detailed reports
- 1 sample pregnant woman with ambiguous D phenotyping reported by a USA lab, Washington DC
- 3/430 among samples with ambigous D phenotype in the French population (Table S1)
- 17 samples "All 20 DIV Type 3 to DIV Type 5 carriers were Caucasians; seventeen were donors or patients from Germany and one patient each was of Turkish, Yugoslavian, and Swiss origin" Caucasian, mainly German
- 1/1174 donors with D negative phenotype United States population (Los Angeles)
Allele or phenotype frequency
Structure mapping
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References
- Grootkerk-Tax MG et al. RHD(T201R, F223V) cluster analysis in five different ethnic groups and serologic characterization of a new Ethiopian variant DARE, the DIII type 6, and the RHD(F223V). Transfusion, 2006. [Citation] [RHeference]
- Sandler SG et al. New laboratory procedures and Rh blood type changes in a pregnant woman. Obstet Gynecol, 2012. [Citation] [RHeference]
- Fichou Y et al. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles. Transfusion, 2013. [Citation] [RHeference]
- von Zabern I et al. D category IV: a group of clinically relevant and phylogenetically diverse partial D. Transfusion, 2013. [Citation] [RHeference]
- Perez-Alvarez I et al. RHD genotyping of serologic RhD-negative blood donors in a hospital-based blood donor center. Transfusion, 2019. [Citation] [RHeference]
Last update: April 22, 2020