weak D or Du phenotype
(ISBT table: not listed)
This entry is a phenotypic characterization.
weak D or Du phenotype,
Molecular data
Nucleotides:
Amino acids:
Hybrid allele encompassing at least one RHCE exon:
NA
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: weak D (last update: Dec. 28, 2020)Reports by D phenotype
- Discrepant D phenotype (negative or positive depending on anti-D reagents and techniques)
- Samples referred for weak D phenotype, not confirmed by serological testing
- Weak D phenotype
- Samples referred for weak D phenotype, not confirmed by serological testing
Other RH phenotypes: RH:
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
- range: 200 - 1100 Ag/RBC, 1 R0r Du sample, tested with 5 monoclonal anti-D (H27, BRAD5, BRAD7, 2B6, BRAD3), and one polyclonal anti-D (Table 1, Figure 3)
- range: 200 - 1300 Ag/RBC, 4 R1r Du samples, tested with 5 monoclonal anti-D (H27, BRAD5, BRAD7, 2B6, BRAD3), and one polyclonal anti-D (Table 1, Figure 3)
- range: 200 - 800 Ag/RBC, 7 R2r Du sample, tested with 5 monoclonal anti-D (H27, BRAD5, BRAD7, 2B6, BRAD3), and one polyclonal anti-D (Table 1, Figure 3)
- range: 100 - 800 Ag/RBC, 1 "R2r u" Du sample, tested with 5 monoclonal anti-D (H27, BRAD5, BRAD7, 2B6, BRAD3), and one polyclonal anti-D (Table 1)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: NA (last update: Dec. 28, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant, see types or alleles (last update: Dec. 28, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: NA, NA (last update: Dec. 28, 2020)Detailed reports
- 13?/55162 among samples C or E positive and positive for "Du test" (55162 samples were typed; 314 were ddCcee, with 63 positive for "Du test" and 154 were ddccEe, with 30 positive for "Du test"; of the 93 "Du positive", 60 underwent molecular analysis) in the French population
- 35/5800 (0.6%) donors had weak, variable, discrepant (initially D negative, D positive by IAT) or mixed-field D typing presumed Caucasian, in the Danish population (91,4% Caucasian)
Allele or phenotype frequency
Structure mapping
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References
- Jones JW et al. Quantitation of Rh D antigen sites on weak D and D variant red cells by flow cytometry. Vox Sang, 1996. [Citation] [RHeference]
- Rouillac C et al. Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes. Blood, 1996. [Citation] [RHeference]
- Avent ND et al. Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the RHD gene. Blood, 1997. [Citation] [RHeference]
- Reid ME et al. Use of LOR-15C9 monoclonal anti-D to differentiate erythrocytes with the partial DvI antigen from those with either partial D antigens or weak D antigens. Immunohematology, 1998. [Citation] [RHeference]
- Müller TH et al. PCR screening for common weak D types shows different distributions in three Central European populations. Transfusion, 2001. [Citation] [RHeference]
- Noizat-Pirenne F et al. Weak D phenotypes and transfusion safety: where do we stand in daily practice? Transfusion, 2007. [Citation] [RHeference]
- Vege S et al. Impact of RHD genotyping on transfusion practice in Denmark and the United States and identification of novel RHD alleles. Transfusion, 2021. [Citation] [RHeference]
Last update: Dec. 28, 2020