RHD*654C
(ISBT table: not listed)
This entry is not counted as an allele.
RHD(M218I), RHD*654C, RHD*654G>C,
Molecular data
Nucleotides:
654G>C;
Amino acids: M218I;
Hybrid allele encompassing at least one RHCE exon:
no
Comments on the molecular basis:
- see also "Descriptions" section on the http://www.rhesusbase.info/RHDstandardRHD.htm
- considered to be a sequencing error
- results are in favour of the sequencing error
- confirms sequencing error
- confirms sequencing error
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D positive (last update: Dec. 20, 2019)Reports by D phenotype
Other RH phenotypes: RH:
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: NA (last update: Aug. 15, 2020)| ce | Ce | cE | CE | |
|---|---|---|---|---|
| ce | 0 | 0 | 0 | 0 |
| Ce | 0 | 0 | 0 | |
| cE | 0 | 0 | ||
| CE | 0 |
Reports by CcEe phenotype
Reports by allele association
Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: not relevant, see types or alleles (last update: Aug. 25, 2020)Detailed information
Antibodies in D negative recipients
Alloimmunization in recipients: NA
Reports
Summary: NA, NA (last update: Aug. 25, 2020)Structure mapping
| Movement | Mouse Input | Touch Input | ||
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| Zoom | Scroll Wheel or Second Mouse Button or Shift+Primary | Pinch (double touch) | ||
| Slab | Ctrl+Second | Not Available |
References
- National Center for Biotechnology Information et al. Data from Genbank submission Online ressource, 1982. — Online ressource — [RHeference]
- Le van Kim C et al. Molecular cloning and primary structure of the human blood group RhD polypeptide. Proc Natl Acad Sci U S A, 1992. [Citation] [RHeference]
- Cartron JP et al. Tentative model for the mapping of D epitopes on the RhD polypeptide. Transfus Clin Biol, 1996. [Citation] [RHeference]
- Okuda H et al. The RHD gene is highly detectable in RhD-negative Japanese donors. J Clin Invest, 1997. [Citation] [RHeference]
- Wagner FF et al. Molecular basis of weak D phenotypes. Blood, 1999. [Citation] [RHeference]
- Legler TJ et al. RHD sequencing: a new tool for decision making on transfusion therapy and provision of Rh prophylaxis. Transfus Med, 2001. [Citation] [RHeference]
- Wagner FF and Flegel WA et al. The Human RhesusBase Online ressource, 2011. — Online ressource — [RHeference]
Last update: April 21, 2020