DIII - phenotypic description
(ISBT table: not listed)
This entry is a phenotypic characterization.
DIII - phenotypic description,
Molecular data
Nucleotides:
Amino acids:
Hybrid allele encompassing at least one RHCE exon:
NA
Comments on the molecular basis:
Extracellular position of one or more amino acid substitutions:
Splicing:
Unconventional prediction methods:
Phenotype
Main D phenotype: D positive (last update: June 16, 2020)Reports by D phenotype
Other RH phenotypes: RH:12,
Serology with monoclonal anti-D
Antigen Density (Ag/RBC)
More phenotype data
Rhesus Similarity Index
Haplotype
Main CcEe phenotype association: ce (last update: Feb. 26, 2020)Alloimmunization
Antibodies in carriers
Antibody specificity: D (RH1)
Summary: allo-anti-D (last update: May 16, 2020)Detailed information
-
Lalezari P et al. Vox Sang (1975)
- Ab specificity: D (RH1)
- Number (auto- or allo-):
- Number listed as allo-: 1
- Number listed as auto-:
- Number of carriers of the allele assessed:
- DAT: negative prior to transfusion, positive post-transfusion of D positive units, became negative again one year later
- Autologuous control: negative when the DAT became negative again
- Elution: anti-D was eluted
- Autoadsorption: ND
- Titer: very high, rapidly rising titers
- Was anti-LW excluded?: ND
- Other antibodies detected: autoantibody
- Cross matches (with Ab and RBCs from different partial types): Table III
- Transfusion history: several D+ RBC units 10 years earlier; the article follows the response to the transfusion of 3 additional D+ RBC units
- Pregnancy history:
- Anti-D Ig history: ND, probably none
- Context: surgery
- Hemolytic consequences: Hematocrit dropped after transfusion of 3 D positive RBC units
- Comment: Anamnestic response
Antibodies in D negative recipients
Alloimmunization in recipients: expected to be possible, see phenotype data
Reports
Summary: NA, NA (last update: Aug. 25, 2020)Structure mapping
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References
- TIPPETT P et al. Observations on subdivisions of the Rh antigen D. Vox Sang, 1962. [Citation] [RHeference]
- Lalezari P et al. Development of direct antiglobulin reaction accompanying alloimmunization in a patient with Rhd (D, category III) phenotype. Vox Sang, 1975. [Citation] [RHeference]
- Lomas C et al. Demonstration of seven epitopes on the Rh antigen D using human monoclonal anti-D antibodies and red cells from D categories. Vox Sang, 1989. [Citation] [RHeference]
- Jones J et al. Selection of monoclonal antibodies for the identification of D variants: ability to detect weak D and to split epD2, epD5 and epD6/7. Vox Sang, 1996. [Citation] [RHeference]
- Tippett P et al. The Rh antigen D: partial D antigens and associated low incidence antigens. Vox Sang, 1996. [Citation] [RHeference]
- Avent ND et al. Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the RHD gene. Blood, 1997. [Citation] [RHeference]
- Kulkarni S et al. Frequency of partial D in Western India. Transfus Med, 2008. [Citation] [RHeference]
Last update: June 16, 2020